| Date | Game | |
| Thu Aug 14, 7:30 ET | at Auburn Auburn, AL | W 1-0 |
| Sun Aug 17, 7:00 ET | at Vanderbilt Nashville, TN | L 0-2 |
| Thu Aug 21, 7:30 ET | vs Detroit Mercy Louisville, Ky. | W 8-0 |
| Sun Aug 24, 7:00 ET | vs Wright State Louisville, Ky. | W 7-2 |
| Thu Aug 28, 3:00 ET | vs USC Upstate Louisville, Ky. | W 9-0 |
| Sun Aug 31, 7:30 ET | vs Coastal Carolina Louisville, Ky. | W 2-0 |
| Thu Sep 4, 7:00 ET | vs Kent State | ACCNX |
| Sun Sep 7, 7:00 ET | vs Dayton Louisville, Ky. | |
| Thu Sep 11, 7:00 ET | at Florida State Tallahassee, Fla. | |
| Sun Sep 14, 1:00 ET | vs Virginia Tech Louisville, Ky. | |
| Fri Sep 19, 7:00 ET | vs Clemson Louisville, Ky. | |
| Thu Sep 25, 7:00 ET | vs Miami Louisville, Ky. | |
| Fri Oct 3, 6:00 ET | at Notre Dame South Bend, Ind. | |
| Thu Oct 9, 7:00 ET | at Wake Forest Winston-Salem, N.C. | |
| Sun Oct 12, 12:00 ET | at Boston College Newton, Mass. | |
| Sat Oct 18, 5:00 ET | vs Virginia Louisville, Ky. | |
| Thu Oct 23, 7:00 ET | at NC State Raleigh, NC | |
| Thu Oct 30, 7:00 ET | vs SMU Louisville, Ky. | |