| Date | Game | |
| Wed Aug 12, 7:30 ET | vs Nebraska Louisville, KY | |
| Sun Aug 16, 7:00 ET | vs IU Indy Louisville, KY | |
| Sun Aug 23, 7:00 ET | vs Belmont Louisville, KY | |
| Thu Aug 27, 7:00 ET | at Dayton Dayton, OH | |
| Sun Aug 30, 1:00 ET | vs Akron Louisville, KY | |
| Thu Sep 3, 7:30 ET | at Kentucky Lexington, KY | |
| Sun Sep 6, 1:00 ET | vs Mercyhurst Louisville, KY | |
| Sat Sep 12, 7:00 ET | vs Pitt Louisville, KY | |
| Thu Sep 17, 10:00 ET | at Stanford Stanford, CA | |
| Sun Sep 20, 7:00 ET | at California Berkeley, CA | |
| Sun Sep 27, 12:00 ET | vs Florida State Louisville, KY | |
| Sat Oct 3, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Sat Oct 10, 6:00 ET | at Clemson Clemson, SC | |
| Fri Oct 23, 7:00 ET | vs Syracuse Louisville, KY | |
| Thu Oct 29, 6:00 ET | at Virginia Charlottesville, VA | |
| Sun Nov 1, 1:00 ET | vs Boston College Louisville, KY | |
| Thu Nov 5, 7:00 ET | vs North Carolina Louisville, KY | |