| Date | Game | |
| Fri Jan 21, 11:00 AM ET | vs Cincinnati LOUISVILLE, KY | W 5-2 |
| Fri Jan 21, 5:00 ET | vs Marshall LOUISVILLE, KY | W 4-3 |
| Sun Jan 23, 11:00 AM ET | vs Miami LOUISVILLE, KY | W 4-3 |
| Sun Jan 23, 5:00 ET | vs Miami Louisville, KY | W 4-3 |
| Sun Feb 6, 1:00 ET | at Vanderbilt Nashville, TN | L 1-6 |
| Fri Feb 11 | vs Ball State Louisville, KY | W 4-3 |
| Sat Feb 12, 4:00 ET | vs Saint Louis LOUISVILLE, KY | W 4-3 |
| Sat Feb 19, 12:00 ET | vs Austin Peay LOUISVILLE, KY | W 6-1 |
| Sat Feb 19, 5:00 ET | vs Bellarmine Louisville, KY | W 6-0 |
| Fri Feb 25, 4:00 ET | vs Duke LOUISVILLE, KY | L 1-6 |
| Sun Feb 27, 12:00 ET | vs North Carolina LOUISVILLE, KY | L 1-6 |
| Sun Mar 6, 1:00 ET | vs Notre Dame LOUISVILLE, KY | L 2-5 |
| Fri Mar 11, 3:00 ET | at Georgia Tech Atlanta, Ga. | L 2-5 |
| Sun Mar 13, 12:00 ET | at Clemson Clemson, SC | L 0-7 |
| Fri Mar 18, 12:00 ET | vs Xavier LOUISVILLE, KY | W 5-2 |
| Fri Mar 25, 3:00 ET | vs Virginia LOUISVILLE, KY | L 1-6 |
| Sun Mar 27, 12:00 ET | vs Virginia Tech Louisville, Ky. | L 3-4 |
| Fri Apr 1, 3:00 ET | at Syracuse Syracuse, N.Y. | L 3-4 |
| Sun Apr 3, 11:00 AM ET | at Boston College Weymouth, MA | L 0-7 |
| Fri Apr 8, 4:00 ET | vs Florida State LOUISVILLE, KY | L 1-4 |
| Sun Apr 10, 12:00 ET | vs Miami LOUISVILLE, KY | L 0-7 |
| Fri Apr 15, 2:00 ET | at NC State Raleigh, N.C. | L 0-7 |
| Sun Apr 17, 11:00 AM ET | at Wake Forest Winston-Salem, N.C. | L 2-5 |
| Wed Apr 20, 3:30 ET | vs Boston College ACC Championship / Rome, Ga. | L 3-4 |