| Date | Game | |
| Fri Jan 20, 10:00 AM ET | vs Northern Illinois Louisville, KY | W 4-3 |
| Fri Jan 20, 5:00 ET | vs Bellarmine Louisville, KY | W 4-1 |
| Sat Jan 28, 12:00 ET | vs Ball State Louisville, KY | L 3-4 |
| Sat Jan 28, 5:00 ET | vs Eastern Kentucky Louisville, KY | W 6-1 |
| Fri Feb 3 | at Vanderbilt Louisville, KY | L 1-6 |
| Sun Feb 5, 11:00 AM ET | vs James Madison Louisville, KY | W 4-3 |
| Fri Feb 10, 11:00 AM ET | vs Cincinnati Louisville, KY | W 5-2 |
| Fri Feb 17, 4:00 ET | vs Austin Peay Louisville, KY | W 6-1 |
| Sun Feb 19, 12:00 ET | vs Memphis Louisville, KY | W 5-2 |
| Fri Feb 24, 4:00 ET | vs Clemson Louisville, KY | L 3-4 |
| Sun Feb 26, 12:00 ET | vs Georgia Tech Louisville, KY | L 0-7 |
| Fri Mar 3, 5:00 ET | at North Carolina Chapel Hill, NC | L 1-6 |
| Sun Mar 5, 11:00 AM ET | at Duke Durham, NC | L 0-7 |
| Sun Mar 12, 3:30 ET | vs Xavier Louisville, KY | W 7-0 |
| Fri Mar 17, 4:00 ET | at Virginia Tech Blacksburg, VA | L 2-5 |
| Sun Mar 19, 10:30 AM ET | at Virginia Charlottesville, VA | L 1-6 |
| Fri Mar 24, 4:00 ET | vs Wake Forest Louisville, KY | L 2-5 |
| Sun Mar 26, 12:00 ET | vs NC State Louisville, KY | L 0-7 |
| Fri Mar 31, 3:30 ET | at Notre Dame South Bend, IN | L 2-5 |
| Thu Apr 6, 12:00 ET | at Miami Coral Gables, FL | L 0-7 |
| Sat Apr 8, 12:00 ET | at Florida State Tallahassee, FL | L 0-4 |
| Fri Apr 14, 4:00 ET | vs Boston College Louisville, KY | L 0-7 |
| Sun Apr 16, 11:30 AM ET | vs Syracuse Louisville, KY | W 4-3 |
| Wed Apr 19, 12:30 ET | vs Boston College Cary, NC | W 4-3 |
| Thu Apr 20, 12:30 ET | vs Florida State Cary, NC | L 0-4 |