| Date | Game | |
| Fri Aug 26, 11:00 AM ET | vs Northern Kentucky Vermillion, S.D. | W 3-0 |
| Fri Aug 26, 8:00 ET | at South Dakota Vermillion, SD | W 3-0 |
| Sat Aug 27, 4:30 ET | vs Missouri Vermillion, S.D. | W 3-0 |
| Wed Aug 31, 7:00 ET | at Western Kentucky Bowling Green, KY | W 3-0 |
| Fri Sep 2, 7:00 ET | vs San Diego Louisville, KY | W 3-1 |
| Sun Sep 4, 2:00 ET | vs Ohio State Louisville, KY | L 1-3 |
| Fri Sep 9, 7:00 ET | vs Purdue Louisville, KY | W 3-0 |
| Sat Sep 10, 7:00 ET | vs Xavier or Lipscomb Louisville, KY | W 3-0 |
| Wed Sep 14, 7:00 ET | at Kentucky Lexington, KY | W 3-2 |
| Sat Sep 17, 10:00 ET | at Stanford Stanford, CA | W 3-1 |
| Fri Sep 23, 7:00 ET | at Miami Coral Gables, FL | W 3-0 |
| Sun Sep 25, 3:00 ET | at Florida State Tallahassee, FL | W 3-0 |
| Fri Sep 30, 7:00 ET | vs Clemson Louisville, KY | W 3-0 |
| Sun Oct 2, 1:00 ET | vs Georgia Tech Louisville, KY | W 3-1 |
| Fri Oct 7, 7:00 ET | at Boston College Chestnut Hill, MA | W 3-0 |
| Sun Oct 9, 1:00 ET | at Syracuse Syracuse, NY | W 3-0 |
| Fri Oct 14, 7:00 ET | vs Virginia Tech Louisville, KY | W 3-1 |
| Sun Oct 16, 1:00 ET | vs Wake Forest Louisville, KY | W 3-1 |
| Fri Oct 21, 7:00 ET | at Virginia Charlottesville, VA | W 3-0 |
| Sun Oct 23, 1:00 ET | at Pittsburgh Pittsburgh, PA | L 2-3 |
| Wed Oct 26, 8:00 ET | vs Notre Dame Louisville, KY | W 3-0 |
| Fri Oct 28, 7:00 ET | vs Duke Louisville, KY | W 3-0 |
| Fri Nov 4, 7:00 ET | vs NC State Louisville, KY | W 3-0 |
| Sun Nov 6, 1:00 ET | vs North Carolina Louisville, KY | W 3-1 |
| Fri Nov 11, 7:00 ET | at Georgia Tech Atlanta, GA | W 3-2 |
| Sun Nov 13, 1:00 ET | at North Carolina Chapel Hill, NC | W 3-0 |
| Fri Nov 18, 6:00 ET | vs Pittsburgh Louisville, Ky. | W 3-0 |
| Wed Nov 23, 6:30 ET | at Notre Dame South Bend, Ind. | W 3-0 |
| Fri Dec 2, 8:00 ET | vs Samford Louisville, KY | W 3-0 |
| Sat Dec 3, 6:00 ET | vs Purdue Louisville, KY | W 3-0 |
| Thu Dec 8 | vs Baylor Louisville, KY | W 3-0 |
| Sat Dec 10, 4:00 ET | vs Oregon Louisville, KY | W 3-2 |
| Thu Dec 15, 9:30 ET | vs Pitt Omaha, Neb. / CHI Health Center | W 3-2 |
| Sat Dec 17, 8:00 ET | vs Texas Omaha, Neb. | L 0-3 |