| Date | Game | |
| Sat Aug 19 | vs RED and BLACK SCRIMMAGE LOUISVILLE, KY | |
| Fri Aug 25, 7:00 ET | vs Troy Louisville, Ky. | W 3-0 |
| Sat Aug 26, 7:00 ET | vs Washington State Louisville, Ky. | W 3-0 |
| Sun Aug 27, 2:00 ET | vs Wright State Louisville, Ky. | W 3-1 |
| Fri Sep 1, 2:00 ET | vs South Dakota Columbia, Mo. | W 3-0 |
| Sat Sep 2, 12:00 ET | vs Northern Kentucky Columbia, Mo. | W 3-0 |
| Sun Sep 3, 3:30 ET | vs Missouri Columbia, Mo. | W 3-0 |
| Wed Sep 6, 7:00 ET | at Dayton Dayton, OH | W 3-2 |
| Sun Sep 10, 1:00 ET | vs Penn State Louisville, Ky. | W 3-0 |
| Wed Sep 13, 8:00 ET | vs Kentucky Louisville, Ky. | W 3-0 |
| Sun Sep 17, 1:00 ET | vs Stanford Louisville, Ky. | L 2-3 |
| Fri Sep 22, 7:00 ET | vs Syracuse Louisville, Ky. | W 3-0 |
| Sun Sep 24, 1:00 ET | vs Boston College Louisville, Ky. | W 3-1 |
| Wed Sep 27, 7:00 ET | at Notre Dame South Bend, Ind. | W 3-0 |
| Sun Oct 1, 4:00 ET | at NC State Raleigh, N.C. | L 1-3 |
| Fri Oct 6, 6:00 ET | at North Carolina Chapel Hill, N.C. | W 3-1 |
| Sun Oct 8, 1:00 ET | at Duke Durham, N.C. | W 3-0 |
| Fri Oct 13, 7:00 ET | vs Pittsburgh Louisville, Ky. | |
| Fri Oct 13, 7:00 ET | vs Pitt Louisville, KY | W 3-0 |
| Sun Oct 15, 1:00 ET | vs Virginia Louisville, Ky. | W 3-0 |
| Fri Oct 20, 7:00 ET | at Wake Forest Winston-Salem, N.C. | W 3-2 |
| Sun Oct 22, 1:00 ET | at Virginia Tech Blacksburg, Va. | W 3-1 |
| Fri Oct 27, 7:00 ET | vs Florida State Louisville, Ky. | W 3-0 |
| Sun Oct 29, 1:00 ET | vs Miami Louisville, Ky. | W 3-0 |
| Fri Nov 3, 7:00 ET | at Georgia Tech Atlanta, Ga. | L 1-3 |
| Sun Nov 5, 1:00 ET | at Clemson Clemson, S.C. | W 3-1 |
| Fri Nov 10, 7:00 ET | vs Duke Louisville, Ky. | W 3-0 |
| Sun Nov 12, 1:00 ET | vs North Carolina Louisville, Ky. | W 3-0 |
| Sat Nov 18 | at Pittsburgh Pittsburgh, PA | |
| Sat Nov 18, 1:00 ET | at Pitt Pittsburgh, PA | L 2-3 |
| Wed Nov 22, 5:00 ET | vs Georgia Tech Louisville, Ky. | W 3-1 |
| Thu Nov 30, 7:00 ET | vs Wright State Louisville, KY | W 3-1 |
| Fri Dec 1, 7:00 ET | vs Western Michigan Louisville, KY | W 3-0 |
| Thu Dec 7, 12:00 ET | vs #3 Creighton Pittsburgh, PA | W 3-2 |
| Sat Dec 9, 4:00 ET | at Pitt Pittsburgh, PA | L 2-3 |