| Date | Game | |
| Fri Aug 29, 6:00 ET | vs Auburn Louisville, KY | W 3-0 |
| Sun Aug 31, 3:00 ET | vs Morehead State Louisville, KY | W 3-0 |
| Mon Sep 1, 3:00 ET | vs St. John's Louisville, KY | W 3-0 |
| Sun Sep 7, 3:00 ET | vs Illinois Louisville, KY | W 3-1 |
| Wed Sep 10, 9:00 ET | vs Texas Forth Worth, TX | L 2-3 |
| Fri Sep 12, 9:00 ET | at Creighton Omaha, NE | W 3-1 |
| Sat Sep 13, 7:30 ET | vs University of Northern Iowa | |
| Sun Sep 14, 1:00 ET | vs Rice | |
| Thu Sep 18, 6:00 ET | vs Kentucky | ESPNU |
| Mon Sep 22, 6:30 ET | vs Western Kentucky | ACCNX |
| Fri Sep 26, 7:00 ET | vs Boston College | ACCNX |
| Sun Sep 28, 1:00 ET | vs Syracuse Louisville, KY | |
| Fri Oct 3, 10:00 ET | at California Berkeley, CA | |
| Sun Oct 5, 5:00 ET | at Stanford Stanford, CA | |
| Fri Oct 10, 7:00 ET | vs Virginia Tech Louisville, KY | |
| Sun Oct 12, 1:00 ET | vs Virginia Louisville, KY | |
| Fri Oct 17, 7:00 ET | vs Southern Methodist Louisville, KY | |
| Sun Oct 19, 1:00 ET | vs Pittsburgh Louisville, KY | |
| Fri Oct 24, 6:30 ET | at Duke University Durham, NC | |
| Sun Oct 26, 3:00 ET | at North Carolina Chapel Hill, NC | |
| Wed Oct 29, 7:00 ET | at Notre Dame South Bend, IN | |
| Sat Nov 1, 3:00 ET | vs Notre Dame Louisville, KY | |
| Fri Nov 7, 7:00 ET | at NC State Raleigh, NC | |
| Sun Nov 9, 1:00 ET | at Wake Forest Winston-Salem, NC | |
| Thu Nov 13, 8:00 ET | vs Florida State Louisville, KY | |
| Sun Nov 16, 1:00 ET | vs Miami Louisville, KY | |
| Fri Nov 21, 7:00 ET | at Georgia Tech Atlanta, GA | |
| Sun Nov 23, 1:00 ET | at Clemson Clemson, SC | |
| Wed Nov 26, 7:00 ET | at Pittsburgh Pittsburgh, PA | |
| Sat Nov 29 | vs Stanford Louisville, KY | |