| Date | Game | |
| Fri Aug 21, 6:00 ET | vs Texas A&M Milwaukee, WI | |
| Sat Aug 22, 4:00 ET | vs Wisconsin Milwaukee, WI | |
| Fri Aug 28, 7:00 ET | vs Indiana Louisville, KY | |
| Mon Aug 31, 6:00 ET | vs Dayton Louisville, KY | |
| Fri Sep 4, 4:00 ET | vs TCU Louisville, KY | |
| Sun Sep 6, 12:00 ET | vs Texas Nashville, TN | |
| Wed Sep 9, 7:00 ET | vs Missouri Louisville, KY | |
| Fri Sep 11, 7:00 ET | at Rice Houston, TX | |
| Sat Sep 12, 2:00 ET | vs Creighton Houston, TX | |
| Sun Sep 13, 1:00 ET | vs Northern Iowa Houston, TX | |
| Wed Sep 16 | at Western Kentucky Bowling Green, KY | |
| Sun Sep 20, 3:00 ET | at Kentucky Lexington, KY | |
| Fri Sep 25 | at Syracuse Syracuse, NY | |
| Sun Sep 27, 1:00 ET | at Boston College Chestnut Hill, MA | |
| Wed Sep 30, 7:00 ET | vs Notre Dame Louisville, KY | |
| Sat Oct 3 | at Notre Dame South Bend, Ind. | |
| Thu Oct 8, 7:00 ET | vs California Louisville, KY | |
| Sun Oct 11, 1:00 ET | vs Stanford Louisville, KY | |
| Fri Oct 16, 7:00 ET | vs Duke Louisville, KY | |
| Sun Oct 18, 1:00 ET | vs North Carolina Louisville, KY | |
| Fri Oct 23, 6:00 ET | at Florida State Tallahassee, FL | |
| Sun Oct 25, 3:30 ET | at Miami Coral Gables, FL | |
| Fri Oct 30, 7:00 ET | vs Clemson Louisville, KY | |
| Sun Nov 1, 12:00 ET | vs Georgia Tech Louisville, KY | |
| Fri Nov 6, 7:00 ET | at Virginia Charlottesville, VA | |
| Sun Nov 8, 1:00 ET | at Virginia Tech Blacksburg, VA | |
| Thu Nov 12, 7:00 ET | at SMU Dallas, TX | |
| Sun Nov 15, 5:00 ET | at Pittsburgh Pittsburgh, PA | |
| Fri Nov 20, 7:00 ET | vs Wake Forest Louisville, KY | |
| Sun Nov 22, 12:00 ET | vs NC State Louisville, KY | |
| Wed Nov 25, 2:00 ET | at North Carolina Chapel Hill, NC | |
| Sat Nov 28, 1:00 ET | vs SMU Louisville, KY | |