| Date | Game | |
| Sat Jan 15 | at Miami Invitational Coral Gables, Fla. | |
| Sat Jan 22, 2:00 ET | vs Princeton Raleigh, N.C. | W 4-3 |
| Sun Jan 23, 12:00 ET | vs Ohio State Raleigh, N.C. | W 4-3 |
| Sun Jan 23, 5:00 ET | vs ETSU Raleigh, N.C. | W 6-1 |
| Sat Jan 29, 11:00 AM ET | vs Iowa State Raleigh, N.C. | W 4-0 |
| Sun Jan 30, 2:00 ET | vs Northwestern/Wake Forest Raleigh, N.C. | W 4-0 |
| Fri Feb 4, 12:00 ET | at Tennessee Knoxville, Tenn. | W 5-2 |
| Sun Feb 6, 2:00 ET | vs South Carolina Raleigh, N.C. | W 7-0 |
| Sun Feb 6, 6:00 ET | vs East Carolina Raleigh, N.C. | W 7-0 |
| Fri Feb 11, 1:00 ET | vs Auburn Madison, Wis. | W 4-2 |
| Sat Feb 12, 1:00 ET | vs #3 Georgia Madison, Wis. | W 4-2 |
| Sun Feb 13, 2:00 ET | vs #2 North Carolina Madison, Wisc. | L 1-4 |
| Sun Feb 20, 1:00 ET | at Texas Austin, Texas | W 4-3 |
| Fri Mar 4, 3:00 ET | vs Florida State Raleigh, N.C. | W 6-1 |
| Sun Mar 6 | vs Miami Raleigh, N.C. | |
| Sun Mar 6, 12:00 ET | vs Miami Raleigh, N.C. | W 4-3 |
| Sun Mar 6, 5:00 ET | vs Elon Raleigh, N.C. | W 7-0 |
| Tue Mar 8 | vs Wake Forest Raleigh, N.C. | |
| Tue Mar 8, 2:00 ET | vs Wake Forest Raleigh, N.C. | W 4-3 |
| Fri Mar 18, 5:00 ET | at Clemson Clemson, S.C. | W 6-1 |
| Sun Mar 20, 2:00 ET | at Georgia Tech Atlanta, Ga. | |
| Sun Mar 20, 2:00 ET | at Georgia Tech Atlanta, Ga. | W 5-2 |
| Fri Mar 25, 3:00 ET | at Boston College Weymouth, MA | W 5-2 |
| Sun Mar 27, 11:00 AM ET | at Syracuse Syracuse, N.Y. | W 6-1 |
| Fri Apr 1, 5:00 ET | vs Duke Raleigh, N.C. | L 3-4 |
| Sun Apr 3, 2:00 ET | vs North Carolina Raleigh, N.C. | L 3-4 |
| Fri Apr 8, 2:00 ET | at Virginia Tech Blacksburg, Va. | W 6-1 |
| Sun Apr 10, 1:00 ET | at Virginia Charlottesville, Va. | L 3-4 |
| Fri Apr 15, 12:00 ET | vs Louisville Raleigh, N.C. | |
| Fri Apr 15, 2:00 ET | vs Louisville Raleigh, N.C. | W 7-0 |
| Sat Apr 16 | vs Notre Dame Raleigh, N.C. | W 7-0 |
| Sun Apr 17 | vs Notre Dame Raleigh, N.C. | |
| Wed Apr 20 | vs 2022 ACC Tournament Rome, Ga. | |
| Thu Apr 21, 3:30 ET | vs Clemson ACC Championship / Rome, Ga. | W 4-0 |
| Fri Apr 22, 3:30 ET | vs Virginia ACC Championship / Rome, Ga. | L 3-4 |
| Sat May 7, 1:40 ET | vs William & Mary NCAA Tournament / Raleigh, NC | W 4-0 |
| Sat May 14, 3:00 ET | vs California NCAA Tournament / Raleigh, NC | W 4-0 |
| Fri May 20, 8:00 ET | vs Duke NCAA Tournament / Champaign, Ill. | L 3-4 |