| Date | Game | |
| Fri Feb 13, 6:30 ET | at FAU Boca Raton, Fla. | L 1-7 |
| Sat Feb 14, 4:00 ET | at FAU Boca Raton, Fla. | W 14-1 |
| Sun Feb 15, 12:00 ET | at FAU Boca Raton, Fla. | W 7-1 |
| Fri Feb 20, 6:00 ET | vs UCF Jacksonville, Fla. (VyStar Ballpark) | L 2-4 |
| Sat Feb 21, 12:00 ET | vs LSU Jacksonville, Fla. (VyStar Ballpark) | L 4-9 |
| Sun Feb 22, 11:00 AM ET | vs Indiana Jacksonville, Fla. (VyStar Ballpark) | W 9-8 |
| Fri Feb 27, 12:00 ET | vs Alabama A&M Cookeville, Tenn. | W 19-2 |
| Sat Feb 28, 12:00 ET | vs UIC Cookeville, Tenn. | W 14-3 |
| Sun Mar 1, 3:00 ET | at Tennessee Tech Cookeville, Tenn. | W 11-0 |
| Tue Mar 3, 4:30 ET | vs Eastern Michigan South Bend, Ind. | W 11-1 |
| Fri Mar 6, 5:00 ET | at Duke Durham, N.C. | W 10-4 |
| Sat Mar 7, 1:00 ET | at Duke Durham, N.C. | L 5-6 |
| Sun Mar 8, 1:00 ET | at Duke Durham, N.C. | W 2-0 |
| Tue Mar 10, 6:00 ET | at Queens Charlotte, N.C. | W 11-6 |
| Fri Mar 13, 6:00 ET | at Louisville Louisville, Ky. | W 14-11 |
| Sat Mar 14, 6:00 ET | at Louisville Louisville, Ky. | L 7-8 |
| Sun Mar 15, 1:00 ET | at Louisville Louisville, Ky. | |
| Tue Mar 17, 4:30 ET | vs Central Michigan South Bend, Ind. | |
| Fri Mar 20, 4:30 ET | vs Clemson South Bend, Ind. | |
| Sat Mar 21, 2:00 ET | vs Clemson Notre Dame, Ind. | |
| Sun Mar 22, 1:00 ET | vs Clemson Notre Dame, Ind. | |
| Tue Mar 24, 4:30 ET | vs Western Michigan South Bend, Ind. | |
| Fri Mar 27, 6:30 ET | vs North Carolina South Bend, Ind. | |
| Sat Mar 28, 3:00 ET | vs North Carolina South Bend, Ind. | |
| Sun Mar 29, 1:00 ET | vs North Carolina South Bend, Ind. | |
| Thu Apr 2, 6:00 ET | at NC State Raleigh, N.C. | |
| Fri Apr 3, 6:00 ET | at NC State Raleigh, N.C. | |
| Sat Apr 4, 2:00 ET | at NC State Raleigh, N.C. | |
| Wed Apr 8, 5:30 ET | vs Michigan State South Bend, Ind. | |
| Fri Apr 10, 5:30 ET | vs Virginia South Bend, Ind. | |
| Sat Apr 11, 2:00 ET | vs Virginia South Bend, Ind. | |
| Sun Apr 12, 1:00 ET | vs Virginia South Bend, Ind. | |
| Tue Apr 14, 5:30 ET | vs Valparaiso South Bend, Ind. | |
| Fri Apr 17, 6:00 ET | at Florida State | |
| Sat Apr 18, 2:00 ET | at Florida State | |
| Sun Apr 19, 1:00 ET | at Florida State | |
| Wed Apr 22 | at Michigan State East Lansing, Mich. | |
| Fri Apr 24, 6:30 ET | vs Boston College South Bend, Ind. | |
| Sat Apr 25, 2:00 ET | vs Boston College South Bend, Ind. | |
| Sun Apr 26, 1:00 ET | vs Boston College South Bend, Ind. | |
| Wed Apr 29, 6:30 ET | vs Milwaukee South Bend, Ind. | |
| Fri May 1, 6:30 ET | vs Stanford South Bend, Ind. | |
| Sat May 2, 2:00 ET | vs Stanford South Bend, Ind. | |
| Sun May 3, 1:00 ET | vs Stanford South Bend, Ind. | |
| Fri May 8, 6:30 ET | vs Oakland South Bend, Ind. | |
| Sat May 9, 2:00 ET | vs Oakland South Bend, Ind. | |
| Sun May 10, 1:00 ET | vs Oakland South Bend, Ind. | |
| Tue May 12, 6:00 ET | vs Dayton Mason, Ohio (Prasco Park) | |
| Thu May 14, 6:00 ET | at Pitt Pittsburgh, PA | |
| Fri May 15, 3:00 ET | at Pitt Pittsburgh, PA | |
| Sat May 16, 1:00 ET | at Pitt Pittsburgh, PA | |