| Date | Game | |
| Mon Nov 3, 7:00 ET | vs Long Island South Bend, Ind. | ACCNX |
| Fri Nov 7, 7:00 ET | vs Detroit Mercy South Bend, Ind. | ACCNX |
| Tue Nov 11, 7:30 ET | vs Eastern Illinois South Bend, Ind. | ACCNX |
| Sun Nov 16, 12:30 ET | at Ohio State Columbus, OH | FS1 |
| Wed Nov 19, 7:00 ET | vs Bellarmine South Bend, Ind. | ACCNX |
| Mon Nov 24, 3:30 ET | vs Kansas Las Vegas, NV | TNT |
| Tue Nov 25, 1:00 ET | vs Rutgers Las Vegas, NV | TNT |
| Wed Nov 26 | vs TBA Las Vegas, NV | TNT/truTV |
| Tue Dec 2, 9:00 ET | vs Missouri South Bend, Ind. | ESPNU |
| Fri Dec 5, 8:00 ET | at TCU Fort Worth, TX | ESPN+ |
| Wed Dec 10, 7:00 ET | vs Idaho South Bend, Ind. | ACCNX |
| Sat Dec 13, 2:00 ET | vs Evansville South Bend, Ind. | ACCN |
| Sun Dec 21, 12:00 ET | vs Purdue Fort Wayne South Bend, Ind. | ACCNX |
| Tue Dec 30, 9:00 ET | at Stanford Palo Alto, CA | ESPN2 |
| Fri Jan 2 | at California Berkeley, CA | ESPN2 |
| Tue Jan 13, 7:00 ET | vs Miami South Bend, Ind. | ESPN2/U |
| Sat Jan 17, 12:00 ET | at Virginia Tech Blacksburg, VA | ACCN |
| Wed Jan 21, 7:00 ET | at North Carolina Chapel Hill | ESPN2 |
| Sat Jan 24, 6:00 ET | vs Boston College South Bend, Ind. | ACCN |
| Tue Jan 27, 7:00 ET | vs Virginia South Bend, Ind. | |
| Sat Jan 31, 6:00 ET | at Syracuse Syracuse, NY | The CW |
| Wed Feb 4, 7:00 ET | at Louisville Louisville, KY | ESPN2/U |
| Sat Feb 7, 4:00 ET | vs Florida State South Bend, Ind. | ACCN |
| Tue Feb 10, 7:00 ET | at SMU Dallas, Texas | |
| Sat Feb 14, 12:00 ET | vs Georgia Tech South Bend, Ind. | The CW |
| Sat Feb 21, 2:00 ET | at Pitt Pittsburgh | ACCN |
| Tue Feb 24, 7:00 ET | vs Duke South Bend, Ind. | ESPN/ESPN2 |
| Sat Feb 28, 12:00 ET | vs NC State South Bend, IN | The CW |
| Wed Mar 4, 9:00 ET | vs Stanford South Bend, Ind. | ESPNU |
| Sat Mar 7, 12:00 ET | at Boston College Chestnut, Hill, Mass. | ESPNU |