| Date | Game | |
| Sun Nov 1, 9:30 AM ET | vs Villanova Rome, Italy | W 74-72 |
| Thu Nov 5, 7:00 ET | vs Mercyhurst South Bend, Ind. | W 83-56 |
| Mon Nov 9, 7:00 ET | vs Eastern Illinois South Bend, Ind. | W 94-70 |
| Wed Nov 11, 7:00 ET | vs South Carolina State South Bend, Ind. | W 99-59 |
| Tue Nov 17, 4:30 ET | vs Florida Las Vegas, NV | ESPN |
| Wed Nov 18 | vs Houston/Rutgers Las Vegas, NV | ESPN |
| Thu Nov 19 | vs TBD Las Vegas, NV | ESPN |
| Tue Nov 24, 8:00 ET | vs Central Michigan South Bend, Ind. | ACCNX |
| Sat Nov 28, 8:00 ET | vs Stonehill South Bend, Ind. | ACCNX |
| Wed Dec 2, 7:15 ET | vs Vanderbilt South Bend, Ind. | ACCN |
| Sat Dec 5, 2:00 ET | vs TCU South Bend, Ind. | ESPNU |
| Tue Dec 8, 7:00 ET | vs Long Island South Bend, Ind. | ACCNX |
| Sat Dec 12, 2:30 ET | vs Ohio State South Bend, Ind. | ACCN |
| Mon Dec 21, 2:00 ET | vs LeMoyne South Bend, Ind. | ACCNX |
| Wed Dec 30, 2:00 ET | vs Stanford South Bend, Ind. | ACCN |
| Wed Jan 6, 7:00 ET | vs Virginia Tech South Bend, Ind. | ACCN |
| Sat Jan 9, 12:30 ET | at Georgia Tech Atlanta, GA | ACCN |
| Tue Jan 12, 7:00 ET | at Wake Forest Winston-Salem, N.C. | ACCN |
| Sat Jan 16, 2:00 ET | vs California South Bend, Ind. | ACCN |
| Wed Jan 20, 7:00 ET | vs Pitt South Bend, Ind. | ESPN2/ESPNU |
| Sat Jan 23, 2:15 ET | at Duke Durham, N.C. | The CW |
| Tue Jan 26, 7:00 ET | at Florida State Tallahassee, Fla. | ACCN |
| Sat Jan 30, 12:30 ET | vs SMU | ACCN |
| Tue Feb 2, 7:00 ET | vs North Carolina South Bend, Ind. | ESPN or ESPN2 |
| Sat Feb 6, 5:30 ET | at Boston College Chestnut, Hill, Mass. | ACCN |
| Sat Feb 13, 2:00 ET | at Virginia Charlottesville, VA | ACCN |
| Wed Feb 17, 9:00 ET | vs Wake Forest South Bend, Ind. | ACCN |
| Sat Feb 20, 4:30 ET | at Miami Coral Gables, FL | ACCN |
| Wed Feb 24, 7:00 AM ET | at NC State Raleigh, NC | ACCN |
| Sat Feb 27, 8:00 ET | vs Syracuse South Bend, Ind. | The CW |
| Tue Mar 2, 7:00 ET | at Clemson Clemson, SC | TBD |
| Sat Mar 6, 2:00 ET | vs Boston College South Bend, Ind. | ACCN |