| Date | Game | |
| Thu Feb 9, 10:00 ET | vs Arizona State San Diego, CA | W 7-1 |
| Fri Feb 10, 7:30 ET | at San Diego State San Diego, CA | L 0-3 |
| Sat Feb 11, 5:00 ET | vs CSUN San Diego, CA | W 5-4 |
| Sat Feb 11, 7:30 ET | vs Northern Illinois San Diego, CA | W 8-2 |
| Sun Feb 12, 12:00 ET | vs Memphis San Diego, CA | W 9-1 |
| Fri Feb 17, 12:00 ET | vs Ohio State Clemson, SC | W 7-2 |
| Sat Feb 18, 10:00 AM ET | vs Northwestern Clemson, SC | L 0-2 |
| Sat Feb 18, 12:30 ET | vs Ohio State Clemson, SC | L 5-6 |
| Sun Feb 19, 10:00 AM ET | vs Northwestern Clemson, SC | L 3-10 |
| Fri Feb 24, 1:30 ET | vs UT Martin Madeira Beach, FL | W 8-7 |
| Sat Feb 25, 11:00 AM ET | vs FIU Madeira Beach, FL | W 4-0 |
| Sat Feb 25, 1:30 ET | vs Siena Madeira Beach, FL | W 2-0 |
| Sun Feb 26, 10:00 AM ET | vs FIU Madeira Beach, FL | W 4-3 |
| Sun Feb 26, 12:30 ET | vs Dartmouth Madeira Beach, FL | W 7-4 |
| Fri Mar 3, 4:00 ET | at Duke Durham, N.C. | W 5-4 |
| Sat Mar 4, 2:00 ET | at Duke Durham, N.C. | L 2-6 |
| Sun Mar 5, 12:00 ET | at Duke Durham, N.C. | L 3-4 |
| Fri Mar 10, 6:00 ET | at NC State Raleigh, N.C. | L 3-11 |
| Sat Mar 11, 2:00 ET | at NC State Raleigh, N.C. | W 10-2 |
| Sat Mar 11, 4:30 ET | at NC State Raleigh, N.C. | W 7-1 |
| Tue Mar 14, 5:00 ET | at Elon Elon, NC | W 16-3 |
| Wed Mar 15, 5:00 ET | at UNCG Greensboro, NC | W 12-3 |
| Thu Mar 16, 5:00 ET | at East Carolina Greenville, N.C. | W 7-0 |
| Tue Mar 21, 5:00 ET | vs Miami South Bend, Ind. | W 11-3 |
| Fri Mar 24, 4:30 ET | vs Syracuse South Bend, IN | W 10-2 |
| Sun Mar 26, 12:30 ET | vs Syracuse South Bend, IN | L 3-5 |
| Sun Mar 26, 4:00 ET | vs Syracuse South Bend, IN | T 0-0 |
| Tue Mar 28, 5:00 ET | vs IUPUI South Bend, IN | W 15-0 |
| Fri Mar 31, 3:00 ET | vs Pitt South Bend, IN | L 5-8 |
| Sun Apr 2, 11:00 AM ET | vs Pitt South Bend, IN | L 11-13 |
| Sun Apr 2, 12:00 ET | vs Pitt South Bend, IN | W 10-2 |
| Sun Apr 2, 1:30 ET | vs Pitt South Bend, IN | W 10-2 |
| Tue Apr 4, 5:00 ET | vs Ball State South Bend, IN | W 10-2 |
| Thu Apr 6, 6:00 ET | at Louisville Louisville, KY | W 1-0 |
| Fri Apr 7, 6:00 ET | at Louisville Louisville, KY | W 13-6 |
| Sat Apr 8, 2:00 ET | at Louisville Louisville, KY | L 2-6 |
| Tue Apr 11, 4:00 ET | at Michigan State East Lansing, MI | W 8-0 |
| Wed Apr 12, 5:00 ET | vs Indiana South Bend, IN | W 9-1 |
| Fri Apr 14, 6:00 ET | vs Virginia Tech South Bend, IN | W 6-1 |
| Sat Apr 15, 2:00 ET | vs Virginia Tech South Bend, IN | L 7-8 |
| Sat Apr 15, 5:00 ET | vs Virginia Tech South Bend, IN | W 11-3 |
| Fri Apr 21, 6:00 ET | at Boston College Chestnut Hill, MA | L 1-4 |
| Sat Apr 22, 2:00 ET | at Boston College Chestnut Hill, MA | W 5-2 |
| Sat Apr 22, 5:00 ET | at Boston College Chestnut Hill, MA | W 6-3 |
| Fri Apr 28, 6:00 ET | vs Florida State South Bend, IN | L 4-5 |
| Sat Apr 29, 1:00 ET | vs Florida State South Bend, IN | L 2-11 |
| Sun Apr 30, 12:00 ET | vs Florida State South Bend, IN | L 0-12 |
| Wed May 10, 3:30 ET | vs Georgia Tech South Bend, IN / ACC Championship | L 1-8 |
| Fri May 19, 5:00 ET | vs Oregon Fayetteville, Ark. / NCAA Regional | L 4-5 |
| Sat May 20, 5:00 ET | vs Harvard Fayetteville, Ark., / NCAA Regional | W 5-2 |
| Sat May 20, 8:55 ET | at Arkansas Fayetteville, AR / NCAA Regional | L 0-5 |