| Date | Game | |
| Mon Nov 2, 7:00 ET | vs Rider Pittsburgh, Pa. | W 95-57 |
| Thu Nov 5, 7:00 ET | vs Buffalo Pittsburgh, Pa. | W 80-61 |
| Sun Nov 8, 8:00 ET | vs Penn State | ESPN2 |
| Fri Nov 13, 6:30 ET | at Butler Indianapolis, Ind. | Peacock |
| Tue Nov 17, 7:00 ET | vs Villanova Pittsburgh, Pa. | |
| Fri Nov 20, 7:00 ET | vs Central Michigan Pittsburgh, Pa. | ACCNX |
| Tue Nov 24, 1:30 ET | vs Oklahoma Fort Myers, Fla. | FS2 |
| Thu Nov 26, 7:00 ET | vs DePaul Fort Myers, Fla. | FS1 |
| Tue Dec 1, 7:00 ET | at Missouri Columbia, Mo. | SEC Network |
| Sat Dec 5, 3:00 ET | vs Tarleton State Pittsburgh, Pa. | ACCNX |
| Wed Dec 9, 6:00 ET | vs West Virginia Pittsburgh, Pa. | ESPN2 |
| Tue Dec 15, 7:00 ET | vs Drexel Pittsburgh, Pa. | ACCNX |
| Fri Dec 18, 7:00 ET | vs Georgia State Pittsburgh, Pa. | ACCNX |
| Mon Dec 21, 7:00 ET | vs Cleveland State Pittsburgh, Pa. | ACCNX |
| Sat Jan 2, 2:00 ET | vs Miami Pittsburgh, Pa. | ESPN/ESPN2 |
| Wed Jan 6, 7:00 ET | at NC State Raleigh, NC | ESPN2/ESPNU |
| Sat Jan 9, 2:00 ET | at Duke Durham, N.C. | CBS |
| Tue Jan 12, 7:00 ET | vs Syracuse Pittsburgh, Pa. | ESPN2/ESPNU |
| Sat Jan 16, 4:00 ET | vs Clemson Pittsburgh, Pa. | ESPN/ESPN2 |
| Wed Jan 20, 7:00 ET | at Notre Dame South Bend, Ind. | ESPN2/ESPNU |
| Sat Jan 23, 7:00 ET | vs Boston College Pittsburgh, PA | ACCN |
| Wed Jan 27, 9:00 ET | vs Virginia Tech Pittsburgh, Pa. | ESPN2/ESPNU |
| Sat Jan 30, 3:00 ET | at Florida State Tallahassee, Fla. | ACCN |
| Tue Feb 2, 9:00 ET | at Louisville Louisville, Ky. | ESPN/ESPN2 |
| Tue Feb 9, 7:00 ET | vs Virginia Pittsburgh, Pa. | ACCN |
| Sat Feb 13, 7:00 ET | at Wake Forest Winston-Salem, N.C. | ACCN |
| Wed Feb 17, 7:00 ET | vs California Pittsburgh, Pa. | ACCN |
| Sat Feb 20, 8:00 ET | vs Georgia Tech Pittsburgh, Pa. | ESPN2 |
| Tue Feb 23, 8:00 ET | at Syracuse Syracuse, N.Y. | ACCN |
| Sat Feb 27, 6:00 ET | at Miami Coral Gables, Fla. | ESPN/ESPN2 |
| Tue Mar 2, 9:00 ET | vs North Carolina Pittsburgh, Pa. | ESPN/ESPN2 |
| Sat Mar 6, 6:00 ET | at SMU Dallas, Texas | ESPNU |