| Date | Game | |
| Fri Feb 11, 5:00 ET | vs Duquesne Pittsburgh, PA | W 9-8 |
| Fri Feb 18, 5:00 ET | vs Siena Pittsburgh, PA | W 12-5 |
| Sun Feb 20, 12:00 ET | vs St. Bonaventure Pittsburgh, PA | W 22-8 |
| Thu Feb 24, 4:00 ET | vs North Carolina Pittsburgh, Pa. | L 5-15 |
| Sun Feb 27, 12:00 ET | at Canisius Buffalo, NY | L 10-12 |
| Sat Mar 5, 1:00 ET | vs Virginia Tech Pittsburgh, Pa. | L 11-12 |
| Thu Mar 10, 6:00 ET | at Duke Durham, N.C. | L 14-15 |
| Sun Mar 13, 1:00 ET | vs Binghamton Pittsburgh, PA | W 17-11 |
| Fri Mar 18, 5:00 ET | at Virginia Charlottesville, VA | L 7-17 |
| Mon Mar 21, 5:00 ET | vs Niagara Pittsburgh, PA | W 15-7 |
| Sat Mar 26, 1:00 ET | vs Boston College Pittsburgh, PA | L 12-19 |
| Mon Mar 28, 5:00 ET | vs Akron Pittsburgh, PA | W 18-6 |
| Sat Apr 2, 12:00 ET | at Syracuse Syracuse, N.Y. | L 6-18 |
| Sat Apr 9, 12:00 ET | vs Louisville Pittsburgh, PA | W 17-10 |
| Tue Apr 12, 4:00 ET | at Penn State University Park, PA | L 7-15 |
| Sat Apr 16, 12:00 ET | at Notre Dame South Bend, Ind. | L 7-19 |
| Tue Apr 19, 5:00 ET | vs George Mason Pittsburgh, PA | W 13-8 |
| Wed Apr 27, 2:00 ET | vs Louisville ACC Championship / Notre Dame, Ind. | W 13-10 |
| Fri Apr 29, 12:00 ET | vs North Carolina ACC Championship / Notre Dame, Ind. | L 6-15 |