| Date | Game | |
| Fri Aug 22, 7:00 ET | at Nebraska Lincoln, NE | L 1-3 |
| Sun Aug 24, 1:00 ET | vs Florida Lincoln, NE | L 2-3 |
| Sun Aug 31, 2:00 ET | vs TCU Pittsburgh, PA | FS1 |
| Mon Sep 1, 7:30 ET | vs Arizona State Pittsburgh, PA | |
| Fri Sep 5, 7:00 ET | vs Pepperdine Pittsburgh, PA | ACCNX |
| Sun Sep 7, 1:00 ET | vs Jacksonville Pittsburgh, PA | |
| Wed Sep 10, 6:30 ET | vs Kentucky | ESPN |
| Fri Sep 12, 6:00 ET | at Wright State Dayton, OH | ESPN+ |
| Sat Sep 13, 2:00 ET | vs Ohio Dayton, OH | |
| Wed Sep 17, 7:00 ET | at Penn State University Park, PA | BTN |
| Fri Oct 3, 7:00 ET | vs Clemson Pittsburgh, PA | ACCNX |
| Sun Oct 5, 12:00 ET | vs Georgia Tech Pittsburgh, PA | ACCN |
| Fri Oct 10, 7:00 ET | at Miami Coral Gables, FL | ACCNX |
| Sun Oct 12, 3:00 ET | at Florida State Tallahassee, FL | ESPN |
| Fri Oct 17, 6:30 ET | at Notre Dame South Bend, IN | ACCNX |
| Sun Oct 19, 1:00 ET | at Louisville Louisville, KY | ESPN |
| Fri Oct 24, 7:00 ET | vs NC State Pittsburgh, PA | ACCNX |
| Sun Oct 26, 1:00 ET | vs Wake Forest Pittsburgh, PA | ACCNX |
| Fri Oct 31, 6:30 ET | at Duke Durham, NC | |
| Fri Nov 7, 7:00 ET | vs Virginia Tech Pittsburgh, PA | ACCNX |
| Sun Nov 9, 1:00 ET | vs Virginia Pittsburgh, PA | ACCN |
| Fri Nov 14, 10:00 ET | at Stanford Stanford, CA | ACCNX |
| Sun Nov 16, 3:00 ET | at California Berkeley, CA | ACCNX |
| Fri Nov 21, 7:00 ET | vs Syracuse Pittsburgh, PA | ACCNX |
| Sun Nov 23, 1:00 ET | vs Boston College Pittsburgh, PA | ACCNX |
| Sat Nov 29, 1:00 ET | at Georgia Tech Atlanta, GA | ACCNX |