| Date | Game | |
| Tue Nov 9, 8:00 ET | vs Maine Cassell Coliseum, Blacksburg, VA | W 82-47 |
| Fri Nov 12, 8:30 ET | at Navy Alumni Hall, Annapolis, MD | W 77-57 |
| Mon Nov 15, 7:00 ET | vs Radford Cassell Coliseum, Blacksburg, VA | W 65-39 |
| Thu Nov 18, 8:00 ET | vs Saint Francis Cassell Coliseum, Blacksburg, VA | W 85-55 |
| Sun Nov 21, 4:00 ET | vs Merrimack Cassell Coliseum, Blacksburg, VA | W 72-43 |
| Wed Nov 24, 9:30 ET | vs Memphis Barclays Center, Brooklyn, NY | L 61-69 |
| Fri Nov 26, 7:00 ET | vs Xavier Barclays Center, Brooklyn, NY | L 58-59 |
| Wed Dec 1, 7:15 ET | at Maryland Spectrum Center, College Park, MD | W 62-58 |
| Sat Dec 4, 2:00 ET | vs Wake Forest Cassell Coliseum, Blacksburg, VA | L 61-80 |
| Wed Dec 8, 9:00 ET | vs Cornell Cassell Coliseum, Blacksburg, VA | W 93-60 |
| Sun Dec 12, 2:00 ET | at Dayton UD Arena, Dayton, OH | L 57-62 |
| Fri Dec 17, 4:00 ET | vs St. Bonaventure Spectrum Center, Charlotte, NC | W 86-49 |
| Wed Dec 22, 9:00 ET | at Duke Cameron Indoor Stadium, Durham, NC | L 65-76 |
| Sat Jan 1, 4:00 ET | vs Pittsburgh Cassell Coliseum, Blacksburg, VA | ESPNU |
| Sat Jan 1, 4:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | ESPNU |
| Sat Jan 1, 4:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | ESPNU |
| Tue Jan 4, 7:00 ET | vs NC State Cassell Coliseum, Blacksburg, VA | L 63-68 |
| Wed Jan 12, 9:00 ET | at Virginia John Paul Jones Arena, Charlottesville, VA | L 52-54 |
| Sat Jan 15, 6:00 ET | vs Notre Dame Cassell Coliseum, Blacksburg, VA | W 79-73 |
| Wed Jan 19, 7:00 ET | at NC State PNC Arena, Raleigh, NC | W 62-59 |
| Sat Jan 22, 12:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | L 63-68 |
| Mon Jan 24, 7:00 ET | vs Louisville Cassell Coliseum, Blacksburg, VA | ESPN/ESPN2 |
| Mon Jan 24, 8:00 ET | at North Carolina Smith Center, Chapel Hill, NC | L 68-78 |
| Wed Jan 26, 7:00 ET | vs Miami Cassell Coliseum, Blacksburg, VA | L 75-78 |
| Sat Jan 29, 3:00 ET | at Florida State Donald L. Tucker Civic Center, Tallahassee, FL | W 85-72 |
| Wed Feb 2, 9:00 ET | vs Georgia Tech Cassell Coliseum, Blacksburg, VA | W 81-66 |
| Sat Feb 5, 7:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | W 76-71 |
| Mon Feb 7, 7:00 ET | vs Pitt Cassell Coliseum, Blacksburg, VA | W 74-47 |
| Sat Feb 12, 6:00 ET | vs Syracuse Cassell Coliseum, Blacksburg, VA | W 71-59 |
| Mon Feb 14, 7:00 ET | vs Virginia Cassell Coliseum, Blacksburg, VA | W 62-53 |
| Sat Feb 19, 4:00 ET | vs North Carolina Cassell Coliseum, Blacksburg, VA | L 57-65 |
| Wed Feb 23, 9:00 ET | at Georgia Tech McCamish Pavilion, Atlanta, GA | W 62-58 |
| Sat Feb 26, 3:00 ET | at Miami Watsco Center, Coral Gables, FL | W 71-70 |
| Sat Feb 26, 3:00 ET | at Miami Watsco Center, Coral Gables, FL | RSN |
| Tue Mar 1, 9:00 ET | vs Louisville Cassell Coliseum, Blacksburg, VA | W 75-43 |
| Sat Mar 5, 2:00 ET | at Clemson Littlejohn Coliseum, Clemson, SC | L 59-63 |
| Wed Mar 9, 7:00 ET | vs Clemson Barclays Center, Brooklyn, NY | W 76-75 |
| Thu Mar 10, 7:00 ET | vs Notre Dame Barclays Center, Brooklyn, NY | W 87-80 |
| Fri Mar 11, 9:30 ET | vs North Carolina Barclays Center, Brooklyn, NY | W 72-59 |
| Sat Mar 12, 8:30 ET | vs Duke Brooklyn, N.Y. | W 82-67 |
| Fri Mar 18, 4:30 ET | vs Texas Fiserv Forum, Milwaukee, WI | L 73-81 |