| Date | Game | |
| Mon Nov 3, 7:00 ET | vs Charleston Southern Blacksburg, VA | W 98-67 |
| Sat Nov 8, 4:00 ET | vs Providence Uncasville, CT | W 107-101 |
| Wed Nov 12, 7:00 ET | vs Saint Joseph's Blacksburg, VA | W 94-59 |
| Sun Nov 16, 2:00 ET | vs Charlotte Blacksburg, VA | W 84-76 |
| Wed Nov 19, 7:00 ET | vs Bryant Blacksburg, VA | W 78-61 |
| Wed Nov 26, 5:00 ET | vs Colorado State Paradise Island, Bahamas | W 66-64 |
| Thu Nov 27, 2:30 ET | vs Saint Mary's Paradise Island, Bahamas | L 66-77 |
| Fri Nov 28, 10:30 AM ET | vs VCU Paradise Island, Bahamas | L 68-86 |
| Tue Dec 2, 7:00 ET | at South Carolina Columbia, SC | W 86-83 |
| Sat Dec 6, 3:00 ET | vs George Mason Blacksburg, VA | W 73-62 |
| Thu Dec 11, 7:00 ET | vs Western Carolina Blacksburg, VA | W 96-74 |
| Sun Dec 14, 12:00 ET | vs UMES Blacksburg, VA | W 82-53 |
| Sat Dec 20, 2:00 ET | vs Elon Blacksburg, VA | W 82-81 |
| Wed Dec 31, 2:00 ET | vs Virginia Blacksburg, VA | W 95-85 |
| Sat Jan 3, 12:00 ET | at Wake Forest Winston-Salem, N.C. | L 78-81 |
| Wed Jan 7, 7:00 ET | vs Stanford Blacksburg, VA | L 68-69 |
| Sat Jan 10, 4:00 ET | vs California Blacksburg, Va. | W 78-75 |
| Tue Jan 13 | at SMU Dallas, Texas | |
| Wed Jan 14, 9:00 ET | at SMU | ESPN2/U |
| Sat Jan 17, 12:00 ET | vs Notre Dame Blacksburg, VA | ACCN |
| Wed Jan 21, 9:00 ET | at Syracuse Syracuse, NY | ACCN |
| Sat Jan 24, 3:30 ET | at Louisville Louisville, KY | The CW |
| Tue Jan 27, 8:00 ET | vs Georgia Tech Blacksburg, VA | ACCN |
| Sat Jan 31, 12:00 ET | vs Duke Blacksburg, VA | ESPN |
| Sat Feb 7, 1:30 ET | at NC State Raleigh, NC | The CW |
| Wed Feb 11, 7:00 ET | at Clemson Clemson, SC | ACCN |
| Sat Feb 14, 2:00 ET | vs Florida State Blacksburg, VA | ACCN |
| Tue Feb 17, 8:00 ET | at Miami Coral Gables, FL | ACCN |
| Sat Feb 21, 12:00 ET | vs Wake Forest Blacksburg, Va. | ACCN |
| Sat Feb 28 | at North Carolina Chapel Hill | ESPN or ESPN2 |
| Tue Mar 3, 9:00 ET | vs Boston College Blacksburg, VA | ESPNU |
| Sat Mar 7, 12:30 ET | at Virginia Charlottesville, VA | The CW |