| Date | Game | |
| Tue Nov 3, 7:00 ET | vs Coppin State Blacksburg, VA | W 88-54 |
| Thu Nov 5, 7:00 ET | vs Mercer Blacksburg, VA | W 96-67 |
| Tue Nov 10, 7:00 ET | vs Iowa Sioux City, SD | W 93-88 |
| Fri Nov 13, 7:00 ET | vs Mount St. Mary's Blacksburg, VA | W 82-62 |
| Mon Nov 16, 7:00 ET | vs Richmond | ACCNX |
| Fri Nov 20, 3:00 ET | vs Northwestern Charleston, SC | ESPN2 |
| Sun Nov 22, 3:30 ET | vs Oklahoma State Charleston, SC | ESPN |
| Fri Nov 27, 5:00 ET | vs Old Dominion Blacksburg, VA | ACCNX |
| Tue Dec 1, 9:00 ET | vs Ole Miss Blacksburg, VA | ACCN |
| Sat Dec 5, 4:30 ET | at West Virginia Morgantown, WV | FS1 |
| Thu Dec 10, 7:00 ET | vs UMES Blacksburg, VA | ACCN |
| Sun Dec 13, 1:00 ET | vs Radford Blacksburg, VA | ACCNX |
| Sat Dec 19 | vs UCF Fort Lauderdale, FL | |
| Mon Dec 21, 6:00 ET | vs VMI Blacksburg, VA | ACCNX |
| Sat Jan 2, 3:30 ET | at Wake Forest Winston-Salem, N.C. | |
| Wed Jan 6, 7:00 ET | at Notre Dame South Bend, Ind. | |
| Sat Jan 9, 8:00 ET | vs Boston College Blacksburg, VA | ACCN |
| Sat Jan 16, 12:00 ET | vs SMU | TBD |
| Wed Jan 20, 7:00 ET | at Florida State Tallahassee, Fla. | |
| Sat Jan 23, 6:00 ET | vs Miami Blacksburg, VA | |
| Wed Jan 27, 9:00 ET | at Pitt Pittsburgh, Pa. | ESPN2/ESPNU |
| Sat Jan 30, 6:00 ET | at Virginia Charlottesville, VA | |
| Tue Feb 2, 8:00 ET | vs Clemson Blacksburg, VA | |
| Wed Feb 10, 9:00 ET | at California Berkeley, Calif. | |
| Sat Feb 13, 4:30 ET | at Stanford Stanford, CA | |
| Wed Feb 17, 7:00 ET | vs NC State Blacksburg, VA | ESPN2/U |
| Sat Feb 20, 12:00 ET | at Boston College Chestnut, Hill, Mass. | ACCN |
| Tue Feb 23, 7:00 ET | vs Virginia Blacksburg, VA | |
| Sat Feb 27, 7:00 ET | vs North Carolina Blacksburg, Va. | ACCN |
| Wed Mar 3, 9:00 ET | vs Syracuse Blacksburg, VA | |
| Sat Mar 6, 12:00 ET | at Georgia Tech Atlanta, GA | |