| Date | Game | |
| Thu Feb 9, 5:00 ET | vs East Carolina Wilmington, NC | W 8-0 |
| Thu Feb 9, 7:00 ET | at UNCW Wilmington, NC | W 5-1 |
| Fri Feb 10, 11:30 AM ET | at UNCW Wilmington, NC | W 6-0 |
| Fri Feb 10, 4:30 ET | vs East Carolina Wilmington, NC | W 4-2 |
| Sat Feb 11, 10:00 AM ET | vs Purdue Fort Wayne Wilmington, NC | W 9-0 |
| Fri Feb 17, 10:00 AM ET | vs Oklahoma State Clearwater, FL | L 9-10 |
| Fri Feb 17, 4:00 ET | vs Nebraska Clearwater, FL | W 6-4 |
| Sat Feb 18, 4:00 ET | vs UCLA Clearwater, FL | L 4-8 |
| Sat Feb 18, 7:00 ET | vs Arizona Clearwater, FL | L 2-6 |
| Sun Feb 19, 12:00 ET | vs South Florida Clearwater, FL | W 4-1 |
| Fri Feb 24, 2:30 ET | vs Abilene Christian Austin, TX | W 11-0 |
| Fri Feb 24, 5:00 ET | at Texas Austin, TX | W 6-5 |
| Sat Feb 25, 11:00 AM ET | at Texas Austin, TX | L 2-8 |
| Sat Feb 25, 11:00 AM ET | vs Texas Southern Austin, TX | W 8-0 |
| Sun Feb 26, 10:30 AM ET | vs Abilene Christian Austin, TX | W 4-1 |
| Fri Mar 3, 3:00 ET | vs NC State Blacksburg, VA | W 7-0 |
| Fri Mar 3, 6:00 ET | vs NC State Blacksburg, VA | |
| Sat Mar 4, 2:00 ET | vs NC State Blacksburg, VA | W 7-3 |
| Sat Mar 4, 2:00 ET | vs NC State Blacksburg, VA | |
| Sun Mar 5, 12:00 ET | vs NC State Blacksburg, VA | W 10-1 |
| Sun Mar 5, 12:00 ET | vs NC State Blacksburg, VA | |
| Tue Mar 7, 4:00 ET | vs Mount St. Mary's Blacksburg, VA | W 6-5 |
| Tue Mar 7, 6:00 ET | vs Mount St. Mary's Blacksburg, VA | W 10-2 |
| Wed Mar 8, 5:00 ET | at Gardner-Webb Boiling Springs, N.C. | W 15-3 |
| Fri Mar 10, 4:00 ET | at North Carolina Chapel Hill, N.C. | W 4-1 |
| Fri Mar 10, 4:00 ET | at North Carolina Chapel Hill, N.C. | |
| Sat Mar 11, 11:00 AM ET | at North Carolina Chapel Hill, NC | L 0-4 |
| Sat Mar 11, 6:00 ET | at North Carolina Chapel Hill, N.C. | W 3-1 |
| Fri Mar 17 | at Georgia Tech Atlanta, GA | |
| Fri Mar 17, 6:00 ET | at Georgia Tech Atlanta, GA | |
| Sat Mar 18 | at Georgia Tech Atlanta, GA | |
| Sat Mar 18, 1:00 ET | at Georgia Tech Atlanta, GA | W 7-4 |
| Sat Mar 18, 3:30 ET | at Georgia Tech Atlanta, GA | W 8-2 |
| Sun Mar 19, 1:00 ET | at Georgia Tech Atlanta, GA | W 5-1 |
| Wed Mar 22, 5:00 ET | vs Charlotte Blacksburg, VA | L 2-3 |
| Fri Mar 24, 6:00 ET | vs Chattanooga Blacksburg, VA | W 12-7 |
| Sat Mar 25, 12:00 ET | vs Chattanooga Blacksburg, VA | W 4-1 |
| Sat Mar 25, 2:00 ET | vs Chattanooga Blacksburg, VA | W 9-5 |
| Tue Mar 28, 6:00 ET | vs Liberty Blacksburg, VA | W 9-5 |
| Fri Mar 31, 6:00 ET | vs Duke Blacksburg, VA | |
| Sat Apr 1, 12:00 ET | vs Duke Blacksburg, VA | L 1-7 |
| Sat Apr 1, 2:00 ET | vs Duke Blacksburg, VA | |
| Sun Apr 2, 12:00 ET | vs Duke Blacksburg, VA | L 1-5 |
| Sun Apr 2, 12:00 ET | vs Duke Blacksburg, VA | |
| Sun Apr 2, 2:00 ET | vs Duke Blacksburg, VA | W 13-8 |
| Tue Apr 4, 3:00 ET | vs Longwood Blacksburg, VA | W 10-2 |
| Tue Apr 4, 6:00 ET | vs Longwood Blacksburg, VA | W 11-1 |
| Thu Apr 6 | at Virginia Charlottesville, VA | |
| Thu Apr 6, 4:00 ET | at Virginia Charlottesville, VA | W 9-8 |
| Fri Apr 7 | at Virginia Charlottesville, VA | |
| Fri Apr 7, 7:00 ET | at Virginia Charlottesville, VA | L 5-6 |
| Sat Apr 8 | at Virginia Charlottesville, VA | |
| Sat Apr 8, 2:00 ET | at Virginia Charlottesville, VA | W 7-0 |
| Tue Apr 11, 6:00 ET | vs Tennessee Blacksburg, VA | L 0-11 |
| Fri Apr 14, 6:00 ET | at Notre Dame South Bend, IN | |
| Fri Apr 14, 6:00 ET | at Notre Dame South Bend, IN | L 1-6 |
| Sat Apr 15, 1:00 ET | at Notre Dame South Bend, IN | |
| Sat Apr 15, 2:00 ET | at Notre Dame South Bend, IN | W 8-7 |
| Sat Apr 15, 5:00 ET | at Notre Dame South Bend, IN | L 3-11 |
| Sun Apr 16, 12:00 ET | at Notre Dame South Bend, IN | |
| Tue Apr 18, 6:00 ET | vs Radford Blacksburg, VA | W 12-1 |
| Thu Apr 20 | vs Florida State Blacksburg, VA | |
| Thu Apr 20, 7:00 ET | vs Florida State Blacksburg, VA | L 1-4 |
| Fri Apr 21 | vs Florida State Blacksburg, VA | |
| Fri Apr 21, 6:00 ET | vs Florida State Blacksburg, VA | L 3-6 |
| Sat Apr 22 | vs Florida State Blacksburg, VA | |
| Sat Apr 22, 4:00 ET | vs Florida State Blacksburg, VA | L 7-16 |
| Tue Apr 25, 3:00 ET | at Marshall Huntington, WV | L 1-2 |
| Wed Apr 26 | vs Florida Tallahassee, FL | |
| Fri Apr 28, 4:00 ET | vs Clemson Blacksburg, VA | W 5-4 |
| Sat Apr 29, 4:00 ET | vs Clemson Blacksburg, VA | W 3-1 |
| Sun Apr 30, 2:00 ET | vs Clemson Blacksburg, VA | L 4-5 |
| Wed May 3, 6:00 ET | at Liberty Lynchburg, VA | W 7-5 |
| Thu May 11, 1:30 ET | vs Louisville South Bend, IN / ACC Championship | W 10-8 |
| Fri May 12, 11:00 AM ET | vs Florida State South Bend, IN / ACC Championship | L 1-9 |
| Fri May 19, 2:00 ET | vs Boston University Athens, Ga. / NCAA Regional | W 6-1 |
| Sat May 20, 1:00 ET | at Georgia Athens, Ga. | L 3-8 |
| Sat May 20, 6:00 ET | vs Boston University Athens, GA / NCAA Regional | W 9-0 |
| Sun May 21, 12:00 ET | at Georgia Athens, Ga. / NCAA Regional | L 3-12 |