| Date | Game | |
| Tue Nov 9, 5:00 ET | vs Davidson | W 76-57 |
| Thu Nov 11, 7:00 ET | at George Washington | W 75-38 |
| Sun Nov 14, 12:00 ET | at George Mason Fairfax, VA | W 81-52 |
| Sun Nov 14, 12:00 ET | vs Georgia Tech | ESPN+ |
| Wed Nov 17, 7:00 ET | vs Coppin St. Blacksburg, Va. | W 85-32 |
| Sat Nov 20, 5:00 ET | vs Campbell Blacksburg, Va. | W 84-39 |
| Fri Nov 26, 10:00 AM ET | at Missouri St. San Juan, Puerto Rico | L 68-76 |
| Sat Nov 27, 10:00 AM ET | at UT- Martin San Juan, Puerto Rico | W 54-49 |
| Wed Dec 1, 7:30 ET | at Wisconsin Madison, Wis. | W 70-60 |
| Sun Dec 5, 2:00 ET | vs Tennessee Blacksburg, Va. | L 58-64 |
| Tue Dec 7, 7:00 ET | at Liberty Lynchburg, Va. | L 40-59 |
| Sun Dec 12, 2:00 ET | vs Radford Blacksburg, Va. | W 89-40 |
| Sun Dec 19, 2:00 ET | at Florida State Tallahassee, Fla. | W 92-75 |
| Thu Dec 30, 7:00 ET | vs Duke Blacksburg, Va. | W 77-55 |
| Sun Jan 2, 4:00 ET | at Wake Forest Winston-Salem, N.C. | W 66-53 |
| Sun Jan 9, 6:00 ET | at North Carolina Chapel Hill, N.C. | L 46-71 |
| Thu Jan 13, 6:00 ET | at Duke Durham, N.C. | W 65-54 |
| Tue Jan 18, 5:00 ET | vs Virginia Blacksburg, Va. | W 69-52 |
| Thu Jan 20, 8:00 ET | vs Pitt Blacksburg, Va. | W 75-65 |
| Sun Jan 23, 4:00 ET | at NC State Raleigh, N.C. | L 45-51 |
| Thu Jan 27, 7:00 ET | at Virginia Charlottesville, Va. | W 71-42 |
| Thu Feb 3, 8:00 ET | at Notre Dame Notre Dame, Ind. | L 55-68 |
| Sun Feb 6, 2:00 ET | vs Boston College Blacksburg, Va. | W 85-62 |
| Tue Feb 8, 6:00 ET | vs Clemson Blacksburg, Va. | W 73-42 |
| Thu Feb 10, 7:00 ET | at Louisville Louisville, KY | ACCN |
| Thu Feb 10, 8:00 ET | vs Georgia Tech Blacksburg, VA | W 73-63 |
| Sun Feb 13, 1:00 ET | vs North Carolina Blacksburg, Va. | W 66-61 |
| Thu Feb 17, 7:00 ET | at Syracuse Syracuse, N.Y. | W 102-53 |
| Sun Feb 20, 2:00 ET | at Louisville Louisville, KY | L 56-70 |
| Thu Feb 24, 6:00 ET | vs Miami Blacksburg, Va. | W 70-63 |
| Sun Feb 27, 6:00 ET | vs NC State Blacksburg, Va. | L 66-68 |
| Thu Mar 3, 11:00 AM ET | vs Syracuse/Clemson Greensboro, N.C. / ACC Tournament | W 82-60 |
| Fri Mar 4, 11:00 AM ET | vs North Carolina | W 87-80 |
| Sat Mar 5, 12:00 ET | vs NC State Greensboro, N.C. / ACC Tournament | L 55-70 |
| Fri Mar 18, 2:30 ET | vs FGCU College Park, Md. / NCAA Tournament | ESPNU |
| Fri Mar 18, 2:30 ET | vs Florida Gulf Coast College Park, Md. / NCAA Tournament | L 81-84 |