| Date | Game | |
| Mon Nov 6, 5:00 ET | vs High Point Blacksburg, Va. | W 94-55 |
| Thu Nov 9, 8:00 ET | vs Iowa Charlotte, N.C. | L 76-80 |
| Thu Nov 16, 6:00 ET | vs Houston Christian Blacksburg, Va. | W 105-36 |
| Mon Nov 20, 6:00 ET | vs UNC Greensboro Blacksburg, Va. | W 72-51 |
| Fri Nov 24, 5:00 ET | vs Kansas George Town, Cayman Islands | W 59-58 |
| Sat Nov 25, 11:00 AM ET | vs Tulane George Town, Cayman Islands | W 76-70 |
| Thu Nov 30, 9:00 ET | at LSU Baton Rouge, La. | L 64-82 |
| Wed Dec 6, 6:00 ET | vs LIU Blacksburg, Va. | W 98-50 |
| Sun Dec 10, 2:00 ET | vs Radford Blacksburg, Va. | W 85-40 |
| Sun Dec 17, 5:30 ET | at Rutgers Piscataway, N.J. | W 84-59 |
| Thu Dec 21, 2:00 ET | vs William & Mary Blacksburg, Va. | W 76-43 |
| Sun Dec 31, 2:00 ET | vs Pitt Blacksburg, VA | W 91-41 |
| Thu Jan 4, 6:00 ET | at Wake Forest Winston-Salem, N.C. | W 82-73 |
| Sun Jan 7, 12:00 ET | vs NC State Blacksburg, Va. | W 63-62 |
| Thu Jan 11, 8:00 ET | vs Miami Blacksburg, Va. | W 76-52 |
| Sun Jan 14, 1:00 ET | at Florida State Tallahassee, FL | L 81-89 |
| Thu Jan 18, 8:00 ET | at Duke Durham, N.C. | L 46-63 |
| Sun Jan 21, 12:00 ET | vs Clemson Blacksburg, Va. | W 74-62 |
| Thu Jan 25, 6:00 ET | vs Georgia Tech Blacksburg, Va. | W 87-69 |
| Sun Jan 28, 12:00 ET | at Syracuse Syracuse, NY | W 75-62 |
| Thu Feb 1, 6:00 ET | vs Virginia Blacksburg, Va. | W 76-63 |
| Sun Feb 4, 12:00 ET | at North Carolina Chapel Hill | W 70-61 |
| Thu Feb 8, 8:00 ET | at NC State Raleigh, N.C. | W 72-61 |
| Sun Feb 11, 1:00 ET | vs Boston College Blacksburg, Va. | W 74-63 |
| Thu Feb 15, 8:00 ET | vs Duke Blacksburg, Va. | W 61-56 |
| Sun Feb 18, 2:00 ET | at Louisville LOUISVILLE, KY | W 86-70 |
| Sun Feb 25, 2:00 ET | vs North Carolina Blacksburg, Va. | W 74-62 |
| Thu Feb 29, 7:00 ET | at Notre Dame South Bend, Ind. | L 58-71 |
| Sun Mar 3, 6:00 ET | at Virginia Charlottesville, Va. | L 75-80 |
| Fri Mar 8, 1:30 ET | vs Miami Greensboro, N.C. | W 55-47 |
| Sat Mar 9, 12:00 ET | vs Notre Dame Greensboro, N.C. | L 53-82 |
| Fri Mar 22, 3:30 ET | vs Marshall Blacksburg, VA | W 92-49 |
| Sun Mar 24, 8:00 ET | vs Baylor Blacksburg, VA | L 72-75 |