| Date | Game | |
| Sat Feb 12, 12:00 ET | at Jacksonville Jacksonville, Fla. | L 6-15 |
| Wed Feb 16, 5:00 ET | at James Madison Harrisonburg, Va. | W 10-9 |
| Sat Feb 19, 1:00 ET | vs VCU Blacksburg, Va. | W 17-9 |
| Wed Feb 23, 3:00 ET | vs Liberty Blacksburg, Va. | L 14-15 |
| Sat Feb 26, 12:00 ET | at Louisville Louisville, Ky. | L 11-14 |
| Wed Mar 2, 4:00 ET | vs Radford Blacksburg, Va. | W 21-3 |
| Sat Mar 5, 1:00 ET | at Pitt Pittsburgh, Pa. | W 12-11 |
| Thu Mar 10, 3:00 ET | vs Notre Dame Blacksburg, Va. | W 13-12 |
| Sat Mar 12, 1:00 ET | vs Winthrop Blacksburg, Va. | W 17-5 |
| Tue Mar 15, 6:00 ET | at Furman Greenville, S.C. | W 21-10 |
| Sat Mar 19, 1:00 ET | vs Syracuse Blacksburg, Va. | L 5-17 |
| Wed Mar 23, 4:00 ET | vs Elon Blacksburg, Va. | W 14-11 |
| Sat Mar 26, 11:00 AM ET | at North Carolina Chapel Hill, NC | L 8-20 |
| Sat Apr 2, 2:00 ET | at Boston College Chestnut Hill, Mass. | L 8-18 |
| Thu Apr 7, 7:00 ET | vs Duke Blacksburg, Va. | L 14-15 |
| Wed Apr 13, 3:00 ET | at Coastal Carolina Conway, S.C. | W 17-6 |
| Thu Apr 21, 7:00 ET | vs Virginia Blacksburg, Va. | L 11-18 |
| Fri Apr 29, 5:00 ET | vs Boston College ACC Championship / Notre Dame, Ind. | L 13-19 |