| Date | Game | |
Thu Feb 9
5:30 ET | at FIU Miami, FL | W 10-1 |
Fri Feb 10
3:00 ET | vs Georgia State Miami, FL | W 11-2 |
Sat Feb 11
10:00 AM ET | vs Kansas City Miami, FL | W 8-1 |
Sat Feb 11
5:30 ET | vs Georgia State | W 11-3 |
| Sun Feb 12 | at FIU | W 4-0 |
Tue Feb 14
5:00 ET | at Furman University Greenville, SC | W 10-0 |
Fri Feb 17
3:00 ET | vs Northwestern Clemson, SC | W 15-2 |
Sat Feb 18
3:00 ET | vs Northwestern Clemson, SC | W 3-2 |
Sat Feb 18
5:29 ET | vs Ohio State Clemson, SC | W 5-1 |
Sun Feb 19
12:30 ET | vs Ohio State Clemson, SC | W 10-0 |
Tue Feb 21
4:00 ET | vs Georgia Clemson, SC | W 7-1 |
Thu Feb 23
6:00 ET | at USF Tampa, FL | W 6-0 |
Fri Feb 24
12:30 ET | vs UIC Tampa, FL | W 9-2 |
Sat Feb 25
9:00 AM ET | vs Michigan State Tampa, FL | W 4-1 |
Sat Feb 25
11:30 AM ET | vs Tennessee Tampa, FL | L 0-1 |
Sun Feb 26
9:00 AM ET | vs Michigan State Tampa, FL | W 8-0 |
Wed Mar 1
4:00 ET | vs Gardner-Webb Clemson, S.C. | W 8-0 |
Wed Mar 1
6:00 ET | vs Gardner-Webb Clemson, SC | W 4-1 |
Sat Mar 4
1:00 ET | vs Syracuse Clemson, SC | W 4-1 |
Sat Mar 4
1:00 ET | vs Syracuse Clemson, SC | W 4-1 |
Sat Mar 4
3:00 ET | vs Syracuse Clemson, SC | W 8-0 |
Wed Mar 8
3:00 ET | vs Mercer Clemson, SC | W 18-0 |
Fri Mar 10
3:00 ET | vs Bryant University Clemson, SC | W 10-1 |
Fri Mar 10
5:30 ET | vs UNC Greensboro Clemson, SC | W 3-0 |
Sat Mar 11
3:00 ET | vs Jacksonville University Clemson, SC | W 9-0 |
Sat Mar 11
5:30 ET | vs UNC Greensboro Clemson, SC | W 6-1 |
| Wed Mar 15 | vs Charlotte Clemson, SC | W 9-1 |
Sat Mar 18
1:00 ET | vs Virginia Clemson, SC | W 4-1 |
Sat Mar 18
3:00 ET | vs Virginia Clemson, SC | W 1-0 |
Sun Mar 19
12:00 ET | vs Virginia Clemson, SC | W 2-0 |
Fri Mar 24
6:00 ET | at Georgia Tech Atlanta, GA | W 9-1 |
Sat Mar 25
3:00 ET | at Georgia Tech Atlanta, GA | W 8-4 |
Sun Mar 26
1:00 ET | at Georgia Tech Atlanta, GA | W 13-0 |
| Tue Mar 28 | vs University of South Carolina Clemson, SC | W 10-0 |
Fri Mar 31
12:00 ET | at Boston College Chestnut Hill, MA | W 8-4 |
Fri Mar 31
3:10 ET | at Boston College Chestnut Hill, MA | W 7-3 |
Sun Apr 2
12:00 ET | at Boston College Chestnut Hill, MA | W 8-0 |
| Wed Apr 5 | vs Furman University Clemson, SC | W 4-1 |
| Thu Apr 6 | vs Florida State Clemson, SC | L 0-7 |
| Fri Apr 7 | vs Florida State Clemson, SC | L 1-4 |
| Sat Apr 8 | vs Florida State Clemson, SC | L 2-3 |
| Tue Apr 11 | at University of South Carolina Columbia, SC | W 4-3 |
Fri Apr 14
2:00 ET | at NC State Raleigh, N.C. | W 4-1 |
Sat Apr 15
2:00 ET | at NC State Raleigh, N.C. | W 6-3 |
Sun Apr 16
4:00 ET | at NC State Raleigh, N.C. | L 5-7 |
| Tue Apr 18 | vs Winthrop University Clemson, SC | W 2-0 |
Fri Apr 21
6:00 ET | vs Pitt Clemson, SC | W 3-2 |
Sat Apr 22
12:00 ET | vs Pitt Clemson, SC | W 2-0 |
Sun Apr 23
12:00 ET | vs Pitt Clemson, SC | W 11-2 |
| Wed Apr 26 | vs Liberty University Clemson, SC | L 4-5 |
Fri Apr 28
4:00 ET | at Virginia Tech Blacksburg, VA | L 4-5 |
Sat Apr 29
4:00 ET | at Virginia Tech Blacksburg, VA | L 1-3 |
Sun Apr 30
2:00 ET | at Virginia Tech Blacksburg, VA | W 5-4 |
Thu May 11
7:30 ET | vs North Carolina South Bend, IN / ACC Championship | W 2-1 |
| Fri May 12 | vs Duke University | L 0-2 |
| Fri May 19 | vs UNC Greensboro | |
Fri May 19
3:00 ET | vs UNC Greensboro Clemson, SC / NCAA Regional | W 17-2 |
Sat May 20
1:00 ET | vs Auburn Clemson, SC | W 7-0 |
Sun May 21
12:00 ET | vs Auburn Clemson, SC / NCAA Regional | L 2-5 |
Sun May 21
3:00 ET | vs Auburn University Clemson, SC | W 5-1 |
Fri May 26
2:00 ET | at Oklahoma Norman, OK / NCAA Super Regional | L 2-9 |
Sat May 27
1:00 ET | at Oklahoma Norman, OK / NCAA Super Regional | L 7-8 |