| Date | Game | |
| Sat Sep 3 | at Syracuse Syracuse, N.Y. | L 7-31 |
| Fri Sep 9 | at UCF Orlando, Fla. | W 20-14 |
| Fri Sep 16 | vs Florida State Louisville, Ky. | L 31-35 |
Sat Sep 24
12:00 ET | vs South Florida Louisville, Ky. | W 41-3 |
Sat Oct 1
12:00 ET | at Boston College | ACCN |
Sat Oct 8
12:00 ET | at Virginia Charlottesville, Va. | ACCN |
| Sat Oct 22 | vs Pitt Louisville, Ky. | |
| Sat Oct 29 | vs Wake Forest Louisville, Ky. | |
| Sat Nov 5 | vs James Madison Louisville, Ky. | |
| Sat Nov 12 | at Clemson Clemson, S.C. | |
| Sat Nov 19 | vs NC State Louisville, Ky. | |
| Sat Nov 26 | at Kentucky Lexington, Ky. | |