| Date | Game | |
| Sat Sep 3 | at Syracuse Syracuse, N.Y. | L 7-31 |
| Fri Sep 9 | at UCF Orlando, Fla. | W 20-14 |
| Fri Sep 16 | vs Florida State Louisville, Ky. | L 31-35 |
Sat Sep 24
12:00 ET | vs South Florida Louisville, Ky. | W 41-3 |
Sat Oct 1
12:00 ET | at Boston College Chestnut Hill, Mass. | L 33-34 |
| Sat Oct 8 | at Virginia Charlottesville, Va. | W 34-17 |
| Sat Oct 29 | vs Wake Forest Louisville, Ky. | W 48-21 |
| Sat Nov 5 | vs James Madison Louisville, Ky. | W 34-10 |
| Sat Nov 12 | at Clemson Clemson, S.C. | L 16-31 |
| Sat Nov 19 | vs NC State Louisville, Ky. | W 25-10 |
Sat Nov 26
3:00 ET | at Kentucky Lexington, Ky. | L 13-26 |
Sat Dec 17
11:00 AM ET | vs Cincinnati Boston, Mass. / Wasabi Fenway Bowl | W 24-7 |