| Date | Game | |
Sat Aug 31
12:00 ET | vs Austin Peay Louisville, Ky. | W 62-0 |
Sat Sep 7
3:30 ET | vs Jacksonville State Louisville, Ky. | W 49-14 |
Sat Sep 21
3:30 ET | vs Georgia Tech Louisville, Ky. | W 31-19 |
Sat Sep 28
3:30 ET | at Notre Dame South Bend, Ind. | L 24-31 |
Sat Oct 5
12:00 ET | vs SMU Louisville, Ky. | L 27-34 |
Sat Oct 12
3:30 ET | at Virginia Charlottesville, Va. | ESPN or ACCN |
| Sat Oct 19 | vs Miami Louisville, Ky. | |
Fri Oct 25
7:30 ET | at Boston College Chestnut Hill, Mass. | ESPN2 |
| Sat Nov 2 | at Clemson Clemson, S.C. | |
| Sat Nov 16 | at Stanford Stanford, Calif. | |
| Sat Nov 23 | vs Pittsburgh Louisville, Ky. | |
| Sat Nov 30 | at Kentucky Lexington, Ky. | |