| Date | Game | |
| Wed Nov 5 | vs FDU South Bend, Ind. | ACCNX |
| Sun Nov 9 | vs Chicago State South Bend, Ind. | ACCNX |
| Wed Nov 12 | vs Akron South Bend, Ind. | |
Sat Nov 15
4:00 ET | vs Michigan Detroit, Mich. | NBC |
| Fri Nov 21 | vs USC South Bend, Ind. | |
| Mon Nov 24 | vs Central Michigan South Bend, Ind. | ACCNX |
Thu Dec 4
9:00 ET | at Ole Miss Oxford, Miss | ESPN2 |
Sun Dec 7
2:00 ET | at Florida State Tallahassee, Fla. | |
| Thu Dec 11 | vs Morehead State South Bend, Ind. | |
| Sun Dec 14 | at James Madison Harrisonburg, VA | |
| Sun Dec 21 | vs Bellarmine South Bend, Ind. | |
| Mon Dec 29 | vs Pitt South Bend, Ind. | |
| Thu Jan 1 | at Georgia Tech Atlanta, GA | |
| Sun Jan 4 | at Duke Durham, N.C. | |
Thu Jan 8
6:00 ET | vs Boston College South Bend, Ind. | |
Sun Jan 11
1:00 ET | vs North Carolina South Bend, Ind. | |
Thu Jan 15
6:00 ET | vs Louisville South Bend, Ind. | |
| Mon Jan 19 | at UConn Storrs, CT | |
| Thu Jan 22 | vs Miami South Bend, Ind. | |
| Sun Jan 25 | vs Clemson South Bend, Ind. | |
| Thu Jan 29 | at California Berkeley, CA | |
| Sun Feb 1 | at Stanford Stanford, CA | |
| Thu Feb 5 | vs Virginia Tech South Bend, Ind. | |
| Sun Feb 8 | at Virginia Charlottesville, VA | |
| Sun Feb 15 | vs NC State South Bend, Ind. | |
Thu Feb 19
6:00 ET | at Wake Forest Winston-Salem, N.C. | |
| Sun Feb 22 | at SMU | |
Thu Feb 26
7:00 ET | vs Syracuse South Bend, Ind. | |
Sun Mar 1
4:00 ET | at Louisville Louisville, KY | |