| Date | Game | |
| Thu Feb 5 | vs Southeastern Louisiana | W 5-3 |
Thu Feb 5
7:00 ET | vs Southeastern Louisiana Clearwater, FL | W 5-3 |
| Fri Feb 6 | vs University of Oregon | W 6-5 |
| Fri Feb 6 | vs Liberty | W 9-4 |
Fri Feb 6
4:00 ET | vs Oregon Clearwater, FL | W 6-5 |
Fri Feb 6
7:00 ET | vs Liberty Clearwater, FL | W 9-4 |
| Sat Feb 7 | vs Auburn | L 5-10 |
Sat Feb 7
4:00 ET | vs Auburn Clearwater, FL | L 5-10 |
| Sun Feb 8 | vs Michigan State | L 2-5 |
Sun Feb 8
10:00 AM ET | vs Michigan State Clearwater, FL | L 2-5 |
| Tue Feb 10 | vs Furman | W 9-1 |
Tue Feb 10
6:00 ET | vs Furman Clemson, SC | W 9-1 |
| Thu Feb 12 | at Texas State San Marcos, TX | L 0-4 |
Thu Feb 12
6:00 ET | vs Texas State San Marcos, TX | L 0-4 |
| Fri Feb 13 | vs BYU | W 7-0 |
| Fri Feb 13 | vs Arkansas | L 0-12 |
Fri Feb 13
5:45 ET | vs Arkansas San Marcos, TX | L 0-12 |
Fri Feb 13
8:00 ET | vs BYU San Marcos, TX | W 7-0 |
| Sun Feb 15 | vs Wichita State | W 9-3 |
Sun Feb 15
10:00 AM ET | vs Wichita State San Marcos, TX | W 9-3 |
Sun Feb 15
11:00 AM ET | vs Arkansas San Marcos, TX | |
| Wed Feb 18 | at Charlotte Charlotte, NC | L 3-8 |
Wed Feb 18
5:00 ET | at Charlotte Charlotte, NC | L 3-8 |
| Fri Feb 20 | vs Lipscomb | W 8-0 |
| Fri Feb 20 | vs Coastal Carolina Clemson, SC | W 8-0 |
Fri Feb 20
12:30 ET | vs Lipscomb Clemson, SC | W 8-0 |
Fri Feb 20
3:00 ET | vs Coastal Carolina Clemson, SC | W 8-0 |
Sat Feb 21
3:00 ET | vs Baylor Clemson, SC | W 8-0 |
Sun Feb 22
12:30 ET | vs Baylor Clemson, SC | W 3-0 |
Wed Feb 25
6:00 ET | at Georgia Athens, GA | W 10-1 |
Fri Feb 27
12:30 ET | vs Wofford Clemson, SC | W 9-1 |
Fri Feb 27
3:00 ET | vs Georgia Southern Clemson, SC | L 7-8 |
Sat Feb 28
3:00 ET | vs Mississippi State Clemson, SC | W 3-0 |
Sun Mar 1
12:30 ET | vs Mississippi State University Clemson, SC | L 1-9 |
Wed Mar 4
6:00 ET | vs College of Charleston Clemson, SC | W 7-0 |
Fri Mar 6
5:00 ET | vs Georgia Tech Clemson, SC | |
Fri Mar 6
6:00 ET | vs Georgia Tech Clemson, SC | W 9-4 |
Sat Mar 7
1:00 ET | vs Georgia Tech Clemson, SC | |
Sat Mar 7
3:00 ET | vs Georgia Tech Clemson, SC | W 1-0 |
Sun Mar 8
1:00 ET | vs Georgia Tech Clemson, SC | |
Sun Mar 8
6:00 ET | vs Georgia Tech Clemson, SC | L 3-4 |
Tue Mar 10
6:00 ET | vs Winthrop Clemson, SC | W 7-3 |
Fri Mar 13
4:00 ET | vs Louisville Clemson, SC | W 8-6 |
Sat Mar 14
1:00 ET | vs Louisville Clemson, SC | W 4-0 |
Sun Mar 15
12:00 ET | vs Louisville Clemson, SC | L 6-7 |
Wed Mar 18
5:00 ET | at Western Carolina Cullowhee, NC | W 7-3 |
Fri Mar 20
6:00 ET | at Notre Dame South Bend, IN | W 4-0 |
Sat Mar 21
1:00 ET | at Notre Dame South Bend, IN | L 3-11 |
Sun Mar 22
12:00 ET | at Notre Dame South Bend, IN | W 4-1 |
Wed Mar 25
7:30 ET | at South Carolina Columbia, SC | W 8-0 |
Fri Mar 27
6:00 ET | vs Florida State Clemson, SC | L 1-4 |
Sat Mar 28
12:00 ET | vs Florida State Clemson, SC | L 2-4 |
Sun Mar 29
6:00 ET | vs Florida State Clemson, SC | L 3-7 |
Tue Mar 31
6:00 ET | vs Gardner-Webb Clemson, SC | W 12-4 |
Thu Apr 2
6:00 ET | at Virginia Tech Blacksburg, VA | W 4-2 |
Thu Apr 2
6:00 ET | at Virginia Tech Blacksburg, VA | |
Fri Apr 3
6:00 ET | at Virginia Tech Blacksburg, VA | L 1-9 |
Fri Apr 3
6:00 ET | at Virginia Tech Blacksburg, VA | |
Sat Apr 4
2:00 ET | at Virginia Tech Blacksburg, VA | |
Sat Apr 4
6:00 ET | at Virginia Tech Blacksburg, VA | L 5-10 |
Fri Apr 10
6:00 ET | at Pitt Pittsburgh, PA | |
Sat Apr 11
7:00 ET | at Pitt Pittsburgh, PA | |
Sun Apr 12
1:00 ET | at Pitt Pittsburgh, PA | |
Tue Apr 14
6:00 ET | vs South Carolina Clemson, SC | |
Fri Apr 17
6:00 ET | vs Virginia Clemson, SC | |
Fri Apr 17
6:00 ET | vs Virginia Clemson, SC | |
Sat Apr 18
1:00 ET | vs Virginia Clemson, SC | |
Sat Apr 18
1:00 ET | vs Virginia Clemson, SC | |
Sun Apr 19
12:00 ET | vs Virginia Clemson, SC | |
Sun Apr 19
12:00 ET | vs Virginia Clemson, SC | |
Tue Apr 21
6:00 ET | vs Presbyterian Clemson, SC | |
Fri Apr 24
6:00 ET | at Duke Durham, NC | |
Sat Apr 25
12:00 ET | at Duke Durham, NC | |
Sun Apr 26
5:00 ET | at Duke Durham, NC | |