| Date | Game | |
Mon Nov 3
11:00 AM ET | vs USC Upstate Clemson, SC | ACCNX |
| Thu Nov 6 | vs Mercer University Clemson, SC | |
| Tue Nov 11 | at South Carolina Columbia, SC | |
Thu Nov 13
7:00 ET | vs American Clemson, SC | |
Sun Nov 16
3:00 ET | vs Louisville Clemson, SC | |
| Sun Nov 23 | at Furman Greenville, SC | ESPN+ |
| Tue Nov 25 | vs ULM Clemson, SC | |
| Fri Nov 28 | vs TBA Nassau, Bahamas | |
| Sun Nov 30 | vs TBA Nassau, Bahamas | |
Thu Dec 4
7:00 ET | at Alabama Tuscaloosa, AL | ESPNU |
Sun Dec 7
2:00 ET | vs App State Clemson, SC | |
| Sun Dec 14 | vs Pitt Clemson, SC | |
| Wed Dec 17 | at Charleston Southern Charleston, SC | |
Sun Dec 21
2:00 ET | vs North Florida Clemson, SC | |
| Sun Dec 28 | at Chicago State Chicago, IL | |
| Thu Jan 1 | at Virginia Charlottesville, VA | |
| Sun Jan 4 | at Miami Coral Gables, FL | |
Thu Jan 8
8:00 ET | vs NC State Clemson, SC | |
| Sun Jan 11 | at Georgia Tech Atlanta, Ga. | |
Sun Jan 18
12:00 ET | vs Wake Forest Clemson, SC | |
| Thu Jan 22 | at Virginia Tech Blacksburg, VA | |
| Sun Jan 25 | at Notre Dame South Bend, Ind. | |
| Thu Jan 29 | vs SMU | |
Sun Feb 1
6:00 ET | vs Florida State Clemson, SC | |
Thu Feb 5
6:00 ET | at North Carolina Chapel Hill, N.C. | |
Sun Feb 8
2:00 ET | vs Boston College Clemson, S.C. | |
| Thu Feb 12 | vs Georgia Tech Clemson, SC | |
Sun Feb 15
2:00 ET | at Syracuse Syracuse, NY | |
Sun Feb 22
2:00 ET | vs Duke Clemson, SC | |
| Thu Feb 26 | at California Berkeley, CA | |
| Sun Mar 1 | at Stanford Stanford, CA | |