| Date | Game | |
Sat Aug 30
3:00 ET | vs Eastern Kentucky Louisville, Ky. | W 51-17 |
Fri Sep 5
7:00 ET | vs James Madison Louisville, Ky. | W 28-14 |
Sat Sep 20
12:00 ET | vs Bowling Green Louisville, Ky. | ACCN |
| Sat Sep 27 | at Pitt Pittsburgh, Pa. | |
| Sat Oct 4 | vs Virginia Louisville, Ky. | |
Fri Oct 17
7:00 ET | at Miami Coral Gables, Fla. | ESPN or ESPN2 |
| Sat Oct 25 | vs Boston College Louisville, Ky. | |
| Sat Nov 1 | at Virginia Tech Blacksburg, Va. | |
| Sat Nov 8 | vs California Louisville, Ky. | |
Fri Nov 14
7:30 ET | vs Clemson Louisville, Ky. | ESPN |
| Sat Nov 22 | at SMU Dallas, Texas | |
| Sat Nov 29 | vs Kentucky Louisville, Ky. | |