| Date | Game | |
| Mon Nov 2 | vs Bellarmine Louisville, KY | |
| Wed Nov 4 | vs Stetson Louisville, KY | |
| Sun Nov 8 | at Southern Indiana Evansville, IN | |
| Tue Nov 10 | vs Lindenwood Louisville, KY | |
| Thu Nov 12 | at Ball State Muncie, IN | |
| Sun Nov 15 | vs UConn Louisville, KY | |
| Tue Nov 17 | vs Tennessee State Louisville, KY | |
Sat Nov 21
11:30 ET | at Alaska Anchorage Anchorage, AK | |
| Sun Nov 22 | vs Chicago State/Seattle Anchorage, AK | |
| Fri Nov 27 | vs Akron Louisville, KY | |
| Sun Nov 29 | vs ETSU Louisville, KY | |
| Wed Dec 2 | at Texas Austin, TX | |
| Sun Dec 6 | vs Eastern Kentucky Louisville, KY | |
| Wed Dec 9 | at Kentucky Lexington, KY | |
| Sun Dec 13 | vs Miami Louisville, KY | |
| Thu Dec 17 | vs Northern Kentucky Louisville, KY | |
| Sun Dec 20 | vs Clemson Louisville, KY | |
| Thu Dec 31 | at Boston College Chestnut Hill, MA | |
| Sun Jan 3 | vs Cal Louisville, KY | |
| Thu Jan 7 | at Florida State Tallahassee, FL | |
| Sun Jan 10 | vs North Carolina Louisville, Ky. | |
| Thu Jan 14 | at Pitt Pittsburgh, Pa. | |
| Sun Jan 17 | at Virginia Tech Blacksburg, VA | |
| Thu Jan 21 | vs Notre Dame Louisville, KY | |
| Sun Jan 24 | at SMU Dallas, Texas | |
| Thu Jan 28 | vs Stanford Louisville, KY | |
| Thu Feb 4 | at Wake Forest Winston-Salem, NC | |
| Sun Feb 7 | at Virginia Charlottesville, VA | |
| Thu Feb 11 | vs Syracuse Louisville, KY | |
| Sun Feb 14 | vs Georgia Tech Louisville, KY | |
| Thu Feb 18 | at Duke Durham, NC | |
| Sun Feb 21 | vs NC State Louisville, Ky. | |
| Sun Feb 28 | at Notre Dame South Bend, Ind. | |