| Date | Game | Result | Notes |
| Fri 10/28/2011 | UNC vs UNC Pembroke | W 100-58 | Exhibition |
| Fri 11/11/2011 | UNC vs Michigan State | W 67-55 | Carrier Classic - San Diego, CA |
| Sun 11/13/2011 | UNC at UNC-Asheville | W 91-75 | |
| Sun 11/20/2011 | UNC vs Mississippi Valley State | W 101-75 | Las Vegas Invitational |
| Tue 11/22/2011 | UNC vs Tennessee State | W 102-69 | Las Vegas Invitational |
| Fri 11/25/2011 | UNC vs South Carolina | W 87-62 | Las Vegas Invitational |
| Sat 11/26/2011 | UNC vs UNLV | L 80-90 | Las Vegas Invitational |
| Wed 11/30/2011 | UNC vs Wisconsin | W 60-57 | ACC/Big Ten Challenge |
| Sat 12/3/2011 | UNC at Kentucky | L 72-73 | |
| Tue 12/6/2011 | UNC vs Evansville | W 97-48 | |
| Sat 12/10/2011 | UNC vs Long Beach State | W 84-78 | Tyler Zeller becomes 66th Tar Heel to break 1,000 career point mark |
| Sat 12/17/2011 | UNC vs Appalachian State | W 97-82 | |
| Mon 12/19/2011 | UNC vs Nicholls | W 99-49 | 72 rebounds are most for UNC since 1954 and second most all time |
| Wed 12/21/2011 | UNC vs Texas | W 82-63 | |
| Thu 12/29/2011 | UNC vs Elon | W 100-62 | |
| Sun 1/1/2012 | UNC vs Monmouth | W 102-65 | School record 26th consecutive win in the Smith Center |
| Sat 1/7/2012 | UNC vs Boston College | W 83-60 | |
| Tue 1/10/2012 | UNC vs Miami | W 73-56 | Dexter Strickland scores 600th career point |
| Sat 1/14/2012 | UNC at Florida State | L 57-90 | Roy Williams' worst loss at UNC |
| Thu 1/19/2012 | UNC at Virginia Tech | W 82-68 | Dexter Strickland tears ACL. Lost for season. |
| Thu 1/26/2012 | UNC vs NC State | W 74-55 | Tyler Zeller career high 17 rebounds |
| Sun 1/29/2012 | UNC vs Georgia Tech | W 93-81 | John Henson passes Sam Perkins for 2nd place on UNC career blocks list (247) |
| Tue 1/31/2012 | UNC at Wake Forest | W 68-53 | UNC becomes first team to win 600 ACC games |
| Sat 2/4/2012 | UNC at Maryland | W 83-74 | Kendall Marshall's 16 assists ties his own record for most in an ACC game |
| Wed 2/8/2012 | UNC vs Duke | L 84-85 | Austin Rivers hits 3-pointer at the buzzer for the Duke win |
| Sat 2/11/2012 | UNC vs Virginia | W 70-52 | Roy Williams 664 career wins ties John Wooden |
| Wed 2/15/2012 | UNC at Miami | W 73-64 | John Henson becomes UNC's 67th career 1,000-point scorer (most in NCAA) |
| Sat 2/18/2012 | UNC vs Clemson | W 74-52 | Clemson 0-56 all-time in Chapel Hill |
| Tue 2/21/2012 | UNC at NC State | W 86-74 | Kendall Marshall 22pts, 13 assts, 0 turnovers |
| Sat 2/25/2012 | UNC at Virginia | W 54-51 | Roy Williams' 250th win at UNC |
| Wed 2/29/2012 | UNC vs Maryland | W 88-64 | Kendall Marshall sets UNC single-season assist record (285) |
| Sat 3/3/2012 | UNC at Duke | W 88-70 | UNC wins 29th ACC regular-season championship |
| Fri 3/9/2012 | UNC vs Maryland | W 85-69 | ACC Tournament Quarterfinals: Kendall Marshall sets ACC single-season assist record (311) |
| Sat 3/10/2012 | UNC vs NC State | W 69-67 | ACC Tournament Semifinals: Kendall Marshall school record third straight double-double in points & assists |
| Sun 3/11/2012 | UNC vs Florida State | L 82-85 | ACC Tournament Finals: First ACC Tournament title for FSU |
| Fri 3/16/2012 | UNC vs Vermont | W 77-58 | NCAA Round of 64 - Greensboro, NC: Kendall Marshall ACC record 16th game with 10+ assists |
| Sun 3/18/2012 | UNC vs Creighton | W 87-73 | NCAA Round of 32 - Greensboro, NC: Kendall Marshall suffers broken right wrist |
| Fri 3/23/2012 | UNC vs Ohio | W 73-65 (OT) | NCAA Sweet 16 - St. Louis, MO: Tyler Zeller 20 pts 22 rebounds |
| Sun 3/25/2012 | UNC vs Kansas | L 67-80 | NCAA Elite 8 - St. Louis, MO: Tyler Zeller finishes career with 1,501 points scored |
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