| Date | Game | Result | Notes |
11/6/2009
7:30 PM | UNC vs. Belmont Abbey | W 107-59 | Exhibition |
11/9/2009
7:00 PM
ESPNU | UNC vs. Florida International | W 88-72 | |
11/11/2009
9:00 PM
ESPNU | UNC vs. NC Central | W 89-42 | |
11/15/2009
4:00 PM
FSS | UNC vs. Valparaiso | W 88-77 | |
11/19/2009
9:15 PM
ESPN2 | UNC vs. Ohio State | W 77-73 | at New York, NY |
11/20/2009
7:15 PM
ESPN2 | UNC vs. Syracuse | L 71-87 | at New York, NY |
11/23/2009
7:30 PM
FSS | UNC vs. Gardner-Webb | W 93-72 | |
11/29/2009
6:45 PM
FSN | UNC vs. Nevada | W 80-73 | Roy Williams' 600th career victory |
12/1/2009
9:00 PM
ESPN | UNC vs. Michigan State | W 89-82 | |
12/5/2009
12:30 PM
CBS | UNC @ Kentucky | L 66-68 | |
12/12/2009
7:30 PM | UNC vs. Presbyterian | W 103-64 | |
12/19/2009
2:00 PM
ESPN | UNC vs. Texas | L 90-103 | at Arlington, TX |
12/22/2009
7:00 PM
FSS | UNC vs. Marshall | W 98-61 | |
12/28/2009
8:30 PM
ESPN2 | UNC vs. Rutgers | W 81-67 | |
12/30/2009
7:00 PM
ESPNU | UNC vs. Albany | W 87-70 | |
1/4/2010
7:00 PM
ESPNU | UNC @ Charleston | L 79-82 (OT) | |
1/10/2010
7:45 PM
FSN | UNC vs. Virginia Tech | W 78-64 | |
1/13/2010
9:00 PM
ESPN | UNC @ Clemson | L 64-83 | |
1/16/2010
2:00 PM
ESPN | UNC vs. Georgia Tech | L 71-73 | |
1/20/2010
7:00 PM
ESPN | UNC vs. Wake Forest | L 69-82 | |
1/26/2010
9:00 PM
Raycom | UNC @ N.C. State | W 77-63 | |
1/31/2010
7:45 PM
FSN | UNC vs. Virginia | L 60-75 | |
2/4/2010
9:00 PM
Raycom | UNC @ Virginia Tech | L 70-74 | |
2/7/2010
2:00 PM
FSN | UNC @ Maryland | L 71-92 | |
2/10/2010
9:00 PM
Raycom/ESPN | UNC vs. Duke | L 54-64 | |
2/13/2010
4:00 PM
ESPN | UNC vs. N.C. State | W 74-61 | |
2/16/2010
9:00 PM
Raycom | UNC @ Georgia Tech | L 51-68 | |
2/20/2010
12:00 PM
CBS | UNC @ Boston College | L 67-71 | |
2/24/2010
7:00 PM
ESPN | UNC vs. Florida State | L 67-77 | |
2/27/2010
2:00 PM
CBS | UNC @ Wake Forest | W 77-68 | |
3/2/2010
8:00 PM
Raycom | UNC vs. Miami | W 69-62 | 2,000th victory in UNC basketball history |
3/6/2010
9:00 PM
ESPN | UNC @ Duke | L 50-82 | |
3/11/2010
7:00 PM
Raycom/ESPN2 | UNC vs. Georgia Tech | L 58-62 | ACC Tournament: Greensboro, NC |
3/16/2010
9:30 PM
ESPN | UNC vs. William & Mary | W 80-72 | NIT: First Round |
3/20/2010
12:00 PM
ESPN | UNC @ Mississippi State | W 76-74 | NIT: Second Round |
3/23/2010
9:00 PM
ESPN | UNC @ UAB | W 60-55 | NIT: Third Round |
3/30/2010
9:00 PM
ESPN2 | UNC vs. Rhode Island | W 68-67 (OT) | NIT: Semifinals, Madison Square Garden |
4/1/2010
7:00 PM
ESPN | UNC vs. Dayton | L 68-79 | NIT Finals, Madison Square Garden; Deon Thompson NCAA record 152 career games played |
| | | Record: 20-17 | |