| Date | Game | Result | Notes |
| Fri 11/5/2010 | UNC vs Barton | W 108-67 | Exhibition |
| Fri 11/12/2010 | UNC vs Lipscomb | W 80-66 | |
| Thu 11/18/2010 | UNC vs Hofstra | W 107-63 | Puerto Rico Tipoff: San Juan, PR |
| Fri 11/19/2010 | UNC vs Minnesota | L 67-72 | Puerto Rico Tipoff: San Juan, PR |
| Sun 11/21/2010 | UNC vs Vanderbilt | L 65-72 | Puerto Rico Tipoff: San Juan, PR |
| Tue 11/23/2010 | UNC vs UNC Asheville | W 80-69 | |
| Sun 11/28/2010 | UNC vs College of Charleston | W 74-69 | |
| Tue 11/30/2010 | UNC at Illinois | L 67-79 | ACC/Big 10 Challenge |
| Sat 12/4/2010 | UNC vs Kentucky | W 75-73 | |
| Wed 12/8/2010 | UNC at Evansville | W 76-49 | |
| Sat 12/11/2010 | UNC vs Long Beach State | W 96-91 | |
| Sat 12/18/2010 | UNC vs Texas | L 76-78 | Greensboro, NC |
| Tue 12/21/2010 | UNC vs William & Mary | W 85-60 | |
| Tue 12/28/2010 | UNC vs Rutgers | W 78-55 | New York, NY |
| Sun 1/2/2011 | UNC vs Saint Francis (PA) | W 103-54 | |
| Sat 1/8/2011 | UNC at Virginia | W 62-56 | |
| Thu 1/13/2011 | UNC vs Virginia Tech | W 64-61 | |
| Sun 1/16/2011 | UNC at Georgia Tech | L 58-78 | |
| Tue 1/18/2011 | UNC vs Clemson | W 75-65 | |
| Wed 1/26/2011 | UNC at Miami | W 74-71 | |
| Sat 1/29/2011 | UNC vs NC State | W 84-64 | |
| Tue 2/1/2011 | UNC at Boston College | W 106-74 | |
| Sun 2/6/2011 | UNC vs Florida State | W 89-69 | |
| Wed 2/9/2011 | UNC at Duke | L 73-79 | |
| Sat 2/12/2011 | UNC at Clemson | W 64-62 | |
| Tue 2/15/2011 | UNC vs Wake Forest | W 78-64 | |
| Sat 2/19/2011 | UNC vs Boston College | W 48-46 | Fewest points scored by UNC in the Smith Center |
| Wed 2/23/2011 | UNC at NC State | W 75-63 | 10th consecutive win over NC State |
| Sun 2/27/2011 | UNC vs Maryland | W 87-76 | |
| Wed 3/2/2011 | UNC at Florida State | W 72-70 | |
| Sat 3/5/2011 | UNC vs Duke | W 81-67 | ACC Regular Season Champion |
| Fri 3/11/2011 | UNC vs Miami | W 61-59 | ACC Tournament: Greensboro, NC |
| Sat 3/12/2011 | UNC vs Clemson | W 92-87 (OT) | ACC Tournament; Harrison Barnes 40 points |
| Sun 3/13/2011 | UNC vs Duke | L 58-75 | ACC Tournament Finals: Greensboro, NC |
| Fri 3/18/2011 | UNC vs Long Island | W 102-87 | NCAA 1st Round - Charlotte, NC |
| Sun 3/20/2011 | UNC vs Washington | W 86-83 | NCAA Round of 32 - Charlotte, NC |
| Fri 3/25/2011 | UNC vs Marquette | W 81-63 | NCAA Round of 16 - Newark, NJ |
| Sun 3/27/2011 | UNC vs Kentucky | L 69-76 | NCAA Round of 8 - Newark, NJ |
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